IFN-α IL-6和IL-17检测对结核病辅助诊断价值

doi:10.3969/j.issn.1006-6233.2024.06.012

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Abstract Objective: To detect and analyze the specificity and sensitivity of serum immune cytokines in mycobacterium tuberculosis (TB) lung disease, and to evaluate its diagnostic value. Methods: A total of 139 patients with suspected pulmonary tuberculosis who were treated in Hebei Chest Hospital from Nov. 2020 to Oct. 2022 were retrospectively selected as the research subjects. According to the latest diagnostic criteria for tuberculosis implemented in 2018 (WS288-2017), 69 cases of confirmed tuberculosis were included in the tuberculosis group, and 70 cases of non-tuberculosis were included in the non-tuberculosis group. The serum levels of immune-related cytokines IL-6, IL-17, and IFN-α were detected by flow immunofluorescence assay, and the diagnostic efficacy of the three factors in tuberculosis was analyzed. Results: The levels of IL-6 and IL-17 in patients with tuberculosis were significantly higher than those in patients without tuberculosis (P<0.05). The concentration of IFN-α in the TB group was slightly higher than that in the non-TB group, There's no statistically significant difference (P>0.05). ROC curve analysis showed that the area under the curve (AUC) of IL-6, IL-17, and IFN-α detection was 0.658, 0.734and 0.571, respectively (P < 0.001). Conclusion: The detection of IL-6 and IL-17 has certain clinical value in the auxiliary diagnosis of tuberculosis.

Key words： Tuberculosis Cytokines IFN-α IL-6 IL-17

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2024.06.012 OR http://www.hbyxzzs.cn/EN/Y2024/V30/I6/942

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