高胆红素血症新生儿血清CKMB NPY及β<sub>2</sub>-MG的水平变化及临床意义

doi:10.3969/j.issn.1006-6233.2024.06.08

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Abstract Objective: To investigate the changes and clinical significance of serum creatine kinase isoenzyme (CreatineKinase-MB, CKMB), neuropeptide Y (Neuropeptide Y, NPY), and β₂-microglobulin (β₂-microglobulin, β₂-MG) levels in hyperbilirubinemic neonates.Methods: A total of 118 hyperbilirubinemic neonates admitted to our hospital from January 2019 to January 2022 were selected as the observation group. According to the total bilirubin (STB) level, they were divided into three groups: mild group (n=58, 220.6μmol/L≤STB≤256.5μmol/L), moderate group (n=42,256.5μmol/L≤STB≤342μmol/L), and severe group (n=18, STB>342μmol/L). Another 112 healthy neonates without jaundice who underwent percutaneous bilirubin measurement in our hospital during the same period were selected as the control group. The levels of CKMB, NPY, and β₂-MG in the control group and observation group were compared. The levels of CKMB, NPY, and β₂-MG in patients with different STB levels in the observation group were compared. According to the percutaneous bilirubin-measured STB level, the patients were divided into the acute phase group and the recovery phase group, and the levels of CKMB, NPY, and β₂-MG in the two groups were compared.Results: The levels of CKMB, NPY, and β₂-MG in the observation group were all higher than those in the control group (P<0.05). Comparison of CKMB, NPY, and β₂-MG levels in patients with different STB levels: mild group < moderate group < severe group (P<0.05). Among the 118 hyperbilirubinemic neonates, there were 67 cases in the acute phase group and 51 cases in the recovery phase group. The levels of CKMB, NPY, and β₂-MG in the acute phase group were all higher than those in the recovery phase group (P<0.05).Conclusion: Serum CKMB, NPY, and β₂-MG levels are closely related to the severity and prognosis of hyperbilirubinemia in neonates. Monitoring these indicators can help assess the progression and prognosis of the condition, providing significant clinical value.

Key words： Creatine kinase isoenzyme Neuropeptide Y β₂-microglobulin Hyperbilirubinemia Palingenesis

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2024.06.08 OR http://www.hbyxzzs.cn/EN/Y2024/V30/I6/923

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