凝血纤溶系统失衡与肺间质纤维化合并呼吸衰竭患者炎性指标相关性分析

doi:10.3969/j.issn.1006-6233.2024.05.026

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Abstract Objective: To investigate the correlation between coagulation and fibrinolysis imbalance and inflammatory indicators in patients with idiopathic pulmonary fibrosis (IPF) and respiratory failure (RF). Methods: A total of 98 patients with IPF treated in our hospital from October 2020 to December 2023 were selected and divided into RF group (n=42) and non-RF group (n=56) based on whether they had RF. An automated coagulation analyzer was used to measure activated partial thromboplastin time (APTT), thrombin time (TT), prothrombin time (PT), and fibrinogen (FIB) levels; D-dimer (D-D) level was measured by immunoturbidimetry; neutrophil percentage (NEUT) and white blood cell count (WBC) were measured by automated blood cell analyzer; C-reactive protein (CRP) level was measured by enzyme-linked immunosorbent assay (ELISA); and procalcitonin (PCT) level was measured by radioimmunoassay. The levels of coagulation and fibrinolysis indicators and inflammatory indicators in the two groups were compared; Pearson correlation analysis was used to analyze the correlation between coagulation and fibrinolysis indicators and inflammatory indicators; and the relationship between coagulation and fibrinolysis indicators and inflammatory indicators and IPF combined with RF was analyzed. Results: APTT, TT, and PT were lower in the RF group than in the non-RF group, while FIB and D-D were higher in the RF group than in the non-RF group, and the differences were statistically significant (P<0.05). NEUT, WBC, CRP, and PCT levels were higher in the RF group than in the non-RF group, and the differences were statistically significant (P<0.05). Pearson correlation analysis showed that APTT, TT, and PT were negatively correlated with NEUT, WBC, CRP, and PCT, while FIB and D-D were positively correlated with NEUT, WBC, CRP, and PCT (P<0.05). APTT, TT, PT, FIB, D-D, NEUT, WBC, CRP and PCT were risk factors for IPF combined with RF. Conclusion: Patients with IPF combined with RF have coagulation and fibrinolysis imbalance and inflammatory response, and coagulation and fibrinolysis imbalance is closely related to the changes in inflammatory indicators, which is worthy of clinical reference.

Key words： Coagulation and fibrinolysis system Idiopathic pulmonary interstitial fibrosis Respiratory failure Inflammatory indicators

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	WANG Yingying
	GU Dongwei
	ZHENG Lei

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WANG Yingying,GU Dongwei,ZHENG Lei. Analysis of the Correlation between Coagulation and Fibrinolysis Imbalance and Inflammatory Indicators in Patients with Idiopathic Pulmonary Fibrosis and Respiratory Failure[J]. HeBei Med, 2024, 30(5): 844-848.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2024.05.026 OR http://www.hbyxzzs.cn/EN/Y2024/V30/I5/844

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