基于双侧前瞻性随机研究生物止血粉联合布地奈德浸润用于慢性鼻窦炎鼻内镜术后价值

doi:10.3969/j.issn.1006-6233.2024.04.031

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (1241 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective: To evaluate the value of bioabsorbable hemostatic powder combined with budesonide soaking in postoperative endoscopic sinus surgery for chronic rhinosinusitis (CRS) based on a prospective randomized controlled study of the bilateral sides of the patients. Methods: A prospective randomized controlled study was conducted on 102 patients with CRS who were admitted to our hospital from April 2021 to May 2023. After endoscopic sinus surgery, budesonide absorbable hemostatic cotton soaked was randomly assigned to fill one side of the nasal cavity (control side), and bioabsorbable hemostatic powder combined with budesonide absorbable hemostatic cotton soaked was filled on the other side (combined side). The bleeding, nasal symptoms, modified endoscopic Lund-Kennedy score, filling material degradation score, ciliary clearance rate, olfactory function, ciliary clearance speed, and safety of the two sides were compared. Results: The bleeding scores on the combined side were lower than those on the control side on the 1st day, 3rd day, 7th day, and 14th day after surgery (P<0.05). The scores of nasal congestion, purulent rhinorrhea, clear rhinorrhea, and facial swelling on the combined side were lower than those on the control side on the 14th day and 1 month after surgery (P<0.05). The modified endoscopic Lund-Kennedy scores on the combined side were lower than those on the control side on the 3rd day, 7th day, and 14th day after surgery (P<0.05). The distribution of filling material degradation scores on the combined side was better than that on the control side on the 7th day and 14th day after surgery (P<0.05). The ciliary clearance rate and ciliary clearance speed on the combined side were higher than those on the control side on the 7th day and 14th day after surgery, and the olfactory function score was lower than that on the control side (P<0.05). There was no significant difference in complications between the combined side and the control side (P>0.05). Conclusion: Bioabsorbable hemostatic powder combined with budesonide soaking does not affect the degradation of filling materials after endoscopic sinus surgery for CRS, and it can synergistically enhance the hemostatic effect, improve nasal symptoms, mucosal status, and olfactory function, and improve ciliary function. It is safe and reliable.

Key words： Chronic sinusitis Biological hemostatic powder Budesonide Bilateral Nasal endoscopy

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	HU Zhiyong
	CHENG Meihao

Cite this article:

HU Zhiyong,CHENG Meihao. Value of Bioabsorbable Hemostatic Powder Combined with Budesonide Soaking in Postoperative Endoscopic Sinus Surgery for Chronic Rhinosinusitis: A Prospective Randomized Bilateral Study[J]. HeBei Med, 2024, 30(4): 687-692.

URL:

http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2024.04.031 OR http://www.hbyxzzs.cn/EN/Y2024/V30/I4/687

[1] Sinha P,Tharakan T,Payne S,et al.Balloon sinus dilation versus functional endoscopic sinus surgery for chronic rhinosinusitis:systematic review and meta-analysis[J].Ann Otol Rhinol Laryngol,2023,132(5):578-588.
[2] Wise SK,Damask C,Roland LT,et al.International consensus statement on allergy and rhinology:allergic rhinitis-2023[J].Int Forum Allergy Rhinol,2023,13(4):293-859.
[3] 陈吉,孙月,高亚,李脊,等.慢性鼻窦炎指南的评价与内容分析[J].中国全科医学,2020,23(13):1583-1591.
[4] Razali RA,Vijakumaran U,Fauzi MB,et al.Maximizing postoperative recovery:the role of functional biomaterials as nasal packs-A comprehensive systematic review without meta-analysis (SWiM)[J].Pharmaceutics,2023,15(5):1534.
[5] Khafagy AG,Maarouf AM.Polyurethane versus chitosan-based polymers nasal packs after functional endoscopic sinus surgery:a prospective randomized double-blinded study[J].Am Rhinol Allergy,2021,35(5):624-630.
[6] Nordstrom A,Jangard M,Svedberg M,et al.Hot saline irrigation in comparison to nasal packing after sinus surgery[J].Laryngoscope Investig Otolaryngol,2021,6(6):1267-1274.
[7] 黄振校,曲静,周煜焜,等.可降解止血粉在慢性鼻窦炎内镜手术中的应用:前瞻性、随机、对照、单盲临床试验[J].中华耳鼻咽喉头颈外科杂志,2021,56(2):144-149.
[8] Phillips KM,Singerman KW,Sedaghat AR.Individual symptom visual analogue scale severity scores for determining EPOS guideline-based chronic rhinosinusitis disease control[J].Rhinology,2022,60(3):229-235.
[9] Tepes I,Kosak Soklic T,Urbancic J.The agreement of the endoscopic Modified Lund-Kennedy scoring in a clinical research group:an observational study[J].Eur Ann Otorhinolaryngol Head Neck Dis,2022,139(4):185-188.
[10] Fokkens WJ,Lund VJ,Hopkins C,et al.European position paper on rhinosinusitis and nasal polyps 2020[J].Rhinology,2020,58(Suppl S29):1-464.
[11] 陈世琴,卫平存,胡云龙,等.糖皮质激素三种不同鼻用法对鼻内镜术后黏膜转归的影响[J].山东大学耳鼻喉眼学报,2022,36(3):195-201.
[12] 张颖,刘勇,龙表利,等.鼻内镜手术联合布地奈德浸润治疗慢性鼻窦炎伴鼻息肉的效果及对嗅觉功能、鼻腔通气功能、复发的影响[J].解放军医药杂志,2022,34(1):101-104.
[13] Liu R,Gong Z.Effect of chitosan-based gel dressing on wound infection,synechia,and granulations after endoscopic sinus surgery of nasal polyps:A meta-analysis[J].Int Wound,2022,19(8):2146-2153.
[14] Megow A,Alsuliman Y,Bouras G,et al.Chitogel following endoscopic sinus surgery promotes a healthy microbiome and reduces postoperative infections[J].Int Forum Allergy Rhinol,2022,12(11):1362-1376.