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| Effect of Reflux Disease on the Expression Levels and Clinical Manifestations of Serum IL-10 TGF-β1 sPD-1 and sPD-L1 in Patients with Chronic Obstructive Pulmonary Disease |
| XU Teng, HAO Lijun, LIU Hongchun, et al |
| Xinjiang Uygur Autonomous Region People's Hospital, Xinjiang Urumqi 830001, China |
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Abstract Objective: To analyze the influence of gastroesophageal reflux disease (GRED) on the expression levels and clinical manifestations of serum interleukin -10(IL-10), transforming growth factor -β1(TGF-β1), soluble programmed death receptor -1(sPD-1) and sPD-1 ligand (sPD-L1) in patients with chronic obstructive pulmonary disease (COPD). Methods: A total of 104 COPD patients admitted to our hospital from January 2022 to September 2023 were divided into combined group and non-combined group according to whether the patients were complicated with reflux disease. The lung function, IL-10, TGF-β1, sPD-L1 and sPD-1 expression levels and clinical manifestations were compared between the two groups. Results: Among 104 COPD patients, 32 cases were complicated with GERD, accounting for 30.77%. IL-10 in the combined group was lower than that in the non-combined group, and its TGF-β1, sPD-1 and sPD-L1 were higher than those in the non-combined group, with statistical significance (P<0.05). FEV1, FEV1/FVC and FEV1% in the combined group were lower than those in the non-combined group, and the difference was statistically significant (P<0.05). The combined group had higher cough symptoms, cough effects, expectoration symptoms, expectoration effects scores, mMRC scores, SGRQ scores and total scores than the non-combined group, and the difference was statistically significant (P<0.05). Conclusion: Nearly one third of COPD patients are complicated with GERD, and GERD is related to the stronger inflammatory reaction and the high expression of sPD-1 and sPD-L1, accompanied by worse lung function and more serious clinical manifestations.
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2024, Vol. 30 
