慢性阻塞性肺疾病合并睡眠呼吸暂停综合征老年患者肺部感染气道炎性损伤及血清SAA CRP水平变化意义

doi:10.3969/j.issn.1006-6233.2024.04.07

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Abstract Objective: To explore pulmonary infection, airway inflammatory injury, changes significance of serum amyloid A (SAA) and C-reactive protein (CRP) in elderly patients with chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea syndrome (OSAS). Methods: A total of 120 elderly patients with COPD and OSAS and 120 elderly patients only with COPD in the hospital were enrolled as COPD combined OSAS group and simple COPD group between January 2021and June 2023. The detection rate of pulmonary infection and levels of serum IL-6, IL-10, IL-1β, COX-2, CRP and SAA were compared between the two groups. The levels of serum indexes in patients with pulmonary infection and those without infection were compared. The evaluation efficiency of serum CRP and SAA for pulmonary infection was analyzed by ROC curves. Results: The detection rate of pulmonary infection in COPD combined OSAS group was higher than that in simple COPD group (28.33% vs 17.50%, P<0.05), and levels of serum IL-6, IL-10, IL-1β, COX-2, CRP and SAA were also higher than those in simple COPD group (P<0.05). The levels of serum CRP and SAA in patients with pulmonary infection were significantly higher than those in patients without infection (P<0.05). ROC curves analysis showed that AUC values of serum CRP, SAA and combined detection for evaluating pulmonary infection were 0.834, 0.894 and 0.929, respectively (P<0.05). Conclusion: The levels of serum CRP, SAA and airway inflammatory injury indexes are abnormally increased in elderly patients with COPD and OSAS. The combined detection of serum CRP and SAA has the best evaluation efficiency for pulmonary infection.

Key words： Chronic obstructive pulmonary disease Elderly Obstructive sleep apnea syndrome Pulmonary infection Airway inflammatory injury Serum amyloid A

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2024.04.07 OR http://www.hbyxzzs.cn/EN/Y2024/V30/I4/564

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