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| Correlation of Serum Chi3L1 NEFAs with Glycolipid Metabolism and Bone Density in Patients with Type 2 Diabetes Mellitus Complicated by Osteoporosis |
| ZHU Rui, MA Hongchuan, CHEN Hualing, et al |
| Honghu People's Hospital, Hubei Honghu 433200, China |
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Abstract Objective: To explore the correlation between serum chitinase 3-like protein 1 (Chi3L1), free fatty acids (NEFAs), glycolipid metabolism, and bone density in patients with type 2 diabetes mellitus (T2DM) complicated by osteoporosis.Methods: A total of 110 T2DM patients admitted to our hospital from January 2020 to April 2023 were selected for the study. Based on the presence of osteoporosis, T2DM patients were divided into the osteoporosis group (38 cases) and non-osteoporosis group (72 cases). Clinical data of T2DM patients were collected. Results: In the osteoporosis group, Chi3L1 levels were significantly lower, while NEFAs levels were significantly higher than those in the non-osteoporosis group (P<0.001). Glycated hemoglobin (HbA1c) and homeostasis model assessment of insulin resistance (HOMA-IR) were significantly higher in the osteoporosis group compared to the non-osteoporosis group (P<0.05). Bone density was significantly lower in the osteoporosis group (P<0.05). Serum Chi3L1 levels were negatively correlated with HbA1c and HOMA-IR, and positively correlated with bone density (P<0.05). NEFAs levels were positively correlated with HbA1c and HOMA-IR, and negatively correlated with bone density (P<0.05). Compared to the non-osteoporosis group, the osteoporosis group had a higher proportion of T2DM patients with low grip strength (P<0.05). Both NEFAs and Chi3L1 were influencing factors for the occurrence of osteoporosis in T2DM patients (P<0.05). Conclusion: Decreased serum Chi3L1 levels and increased NEFAs levels are associated with the occurrence of osteoporosis in T2DM patients and are significantly correlated with glycolipid metabolism and bone density.
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2024, Vol. 30 
