急性胰腺炎继发器官功能衰竭患者凝血功能及外周血TIM-3 TAT ACE2水平变化分析

doi:10.3969/j.issn.1006-6233.2024.03.015

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Abstract Objective: This study aimed to investigate alterations in coagulation function among patients with acute pancreatitis (AP) and secondary organ failure (OF) and analyze variations in peripheral blood levels of T cell immunoglobulin and mucin domain 3 (TIM-3), thrombin-antithrombin complex (TAT), and angiotensin-converting enzyme 2 (ACE2). Methods: Conducted between August 2020 and August 2022, the study involved 118 patients with AP admitted for treatment. Patient severity was assessed using the Atlanta Classification and categorized into mild (n=72) and severe (n=46) groups. Coagulation function indices and peripheral blood TIM-3, TAT, ACE2 levels were compared between the groups, investigating the relationship between secondary organ failure and these parameters. Results: Patients in the severe group exhibited significantly elevated coagulation function indices (PT, INR, APTT, and FIB) and higher peripheral blood TIM-3 and TAT levels compared to the mild group, while ACE2 levels were lower (P<0.05). Similarly, the secondary OF group showed markedly higher coagulation function indices and peripheral blood TIM-3 and TAT levels than the non-OF group, with lower ACE2 levels (P<0.05). Multifactorial analysis indicated that PT, INR, APTT, FIB, TIM-3, TAT, and ACE2 influenced the onset of secondary organ failure. The area under the ROC curve for secondary organ failure was 0.846, 0.926, 0.819, 0.862, 0.751, 0.847, and 0.858 for PT, INR, APTT, FIB, TIM-3, TAT, and ACE2, respectively. Conclusion: In patients with acute pancreatitis, abnormal coagulation and elevation of TIM-3, TAT and decreased ACE 2 in peripheral blood are strongly associated with disease severity, with potential predictive value for the risk of organ failure secondary to acute pancreatitis.

Key words： Acute pancreatitis Organ failure Coagulation function T cell immunoglobulin mucin domain 3 Thrombin-antithrombin complex Angiotensin-converting enzyme 2

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	LI Jun
	WEI Guofeng
	CAI Zhaohui
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LI Jun,WEI Guofeng,CAI Zhaohui, et al. Analysis of Coagulation Function and Peripheral Blood TIM-3 TAT ACE2 Levels in Patients with Acute Pancreatitis and Secondary Organ Failure[J]. HeBei Med, 2024, 30(3): 436-440.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2024.03.015 OR http://www.hbyxzzs.cn/EN/Y2024/V30/I3/436

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