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| Predictive Value of Fragmented QRS Complex on Electrocardiogram Combined with Serum pro-BNP for Heart Failure in Patients with Acute Anterior Myocardial Infarction |
| HE Peijuan, WU Jinpan, HU Juanjuan, et al |
| The First Affiliated Hospital of Air Force Military Medical University, Shaanxi Xi'an 710032, China |
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Abstract Objective: To investigate the predictive value of fragmented QRS (fQRS) complex on electrocardiogram combined with serum pro-brain natriuretic peptide (pro-BNP) for heart failure in patients with acute anterior myocardial infarction (AAMI). Methods: A total of 145 patients with AAMI were admitted to the hospital from February 2020 to February 2023. They were divided into two groups according to the presence or absence of heart failure in 3 months after percutaneous coronary intervention (PCI). General data of patients in the heart failure group and the non-heart failure group were collected. All patients completed routine 12-lead electrocardiogram and serum pro-BNP level detection. Logistic regression analysis was performed to identify the influencing factors of heart failure in patients with AAMI. The value of fQRS complex, pro-BNP, and their combination in predicting heart failure in patients with AAMI was analyzed using the ROC curve. Results: A total of 76 (52.41%) patients developed heart failure and 69 (47.59%) patients did not. Serum creatinine (Scr) level and therapeutic time window after onset in the heart failure group were higher/longer than those in the non-heart failure group. The diseased branches before operation were more than the non-heart failure group (P<0.05). Patients with fQRS complex on electrocardiogram in the heart failure group were more than the non-heart failure group, and pro-BNP level was higher than that in the non-heart failure group (P<0.05). fQRS complex on electrocardiogram and pro-BNP were influencing factors of heart failure in patients with AAMI (P<0.05). For single prediction of heart failure in patients with AAMI, the AUC of pro-BNP was the highest (0.800), with sensitivity of 50.00% and specificity of 85.65%. The sensitivity and specificity of joint prediction with the two indicators were of 84.21% and 69.57%. Conclusion: fQRS and pro-BNP are influencing factors for heart failure in AAMI patients. fQRS and pro-BNP have high prognostic value in HF in AAMI patients. The combination of them can significantly improve sensitivity and has higher prognostic value, which can be used as an auxiliary detection index.
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2024, Vol. 30 
