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| Evaluation of Combination of Osteopontin and Cystatin C in Diagnosis of Coronary Heart Disease |
| Sun Qitian, Xue Tingyun, Yan Zhenrong, et al |
| The Affiliated Hospital of Chengde Medical University, Hebei Chengde 067000, China |
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Abstract Objective: To evaluate the combination of osteopontin and cystatin C in diagnosis of coronary heart disease. Methods: Serum levels of OPN and Cys-C were measured in 148 patients who underwent coronary angiography in our hospital. These patients were grouped according to the diseases they had and clinical data of them were collected. Results: Logistic regression analysis showed that OPN and Cys-c could independently predict CHD.ROC curve showed that the AUC of osteopontin combined with cystatin C in the diagnosis of CHD was 0.830, the sensitivity was 76.42%, and the specificity was 81.16%. The results of comparison of OPN and Cys-c levels between different groups showed OPN level was significantly higher in the UAP group than that in SAP group, but significantly lower than that in the AMI group. The level of Cys-c increased in UAP group compared with that in SAP group and the level of Cys-c decreased in AMI group compared with that in UAP group(P<0.05). But the changes of Cys-c in different groups were not statistically significant(P>0.05). Conclusion: Our study demonstrated OPN and Cys-c have diagnostic values for CHD, and dynamic detections of OPN and Cys-c are helpful for disease monitoring.
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2024, Vol. 30 
