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| Effect of Metadoxine Treatment on Time to Awakening Time to Symptom Disappearance and Oxidative Stress in Patients with Acute Alcohol Intoxication |
| WANG Xiaoyin, ZUO Shuang, XU Liyou, et al |
| Hefei Second People's Hospital, Anhui Hefei 230000, China |
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Abstract Objective: To explore the effects of Metadoxine treatment in patients with acute alcoholism. Methods: A total of 104 patients with acute alcoholism admitted to the emergency department of our hospital from January 2020 to December 2022 were selected as the study subjects, and were randomly divided into the conventional group (n=52) and the Metadoxine group (n=52) by using the method of randomized numerical table. The control group was given conventional treatment, and the observation group was given Metadoxine on the basis of conventional treatment. Clinical indexes (awakening time, symptom disappearance time) were recorded in the two groups, blood gas indexes [blood oxygen saturation (SaO2), partial pressure of oxygen (PO2)] and breath alcohol concentration (BrAC) levels were compared between the two groups before and after treatment, oxidative stress [superoxide dismutase (SOD)] status was compared between the two groups before and after treatment, and liver and kidney function [alanine aminotransferase (ALT), aspartate aminotransferase (AST), blood creatinine (Scr), urea nitrogen (BUN)], and coagulation function [prothrombin time (PT), prothrombin time (TT), activated partial thromboplastin time (APTT), fibrinogen (FIB)]. Results: The awakening time and symptom disappearance time of the Metadoxine group were shorter than that of the conventional group (P all <0.05); after treatment, the levels of SaO2, PO2, SOD and FIB of the two groups increased compared with those before treatment, and the level of change of Metadoxine was higher than that of the conventional group (P all <0.05); the levels of BrAC, liver and renal function indexes (ALT, AST, Scr, BUN), and some of the indicators of coagulation function (PT, TT, APTT) levels were lower than before treatment, and the level of change of Metadoxine was higher than that of the conventional group (all P<0.05). Conclusion: Metadoxine can shorten the awakening time and symptom disappearance time of patients with acute alcohol intoxication, improve the blood gas status of patients, alleviate the oxidative stress reaction of patients, and improve the liver and kidney function and coagulation function of patients.
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2024, Vol. 30 
