miR-181b miR-210 miR-126在妊娠期高血压疾病中的表达及与炎症反应的相关性

doi:10.3969/j.issn.1006-6233.2024.01.029

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Abstract Objective: To explore the expressions of serum micrornA-181b (miR-181b), miR-210 and miR-126 in hypertensive diseases in pregnancy (HDP) and its correlation with inflammation response.Methods:A total of 213 cases of singleton pregnant women with HDP treated at Chengde Maternal and Child Health Hospital from January 2018 to December 2019 were selected as the observation group. Based on the severity of the condition, they were divided into gestational hypertension (GH group, 62 cases), mild preeclampsia (MP group, 90 cases), and severe preeclampsia (SP group, 61 cases). Additionally, 78 healthy pregnant women treated during the same period in the same hospital were selected as the control group. The relative expression levels of miR-181b, miR-210, and miR-126, as well as serum interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-10 (IL-10), interleukin-17 (IL-17), tumor necrosis factor-α (TNF-α), monocyte chemoattractant protein-1 (MCP-1), and vascular cell adhesion molecule-1 (VCAM-1) levels were detected. The correlation between various indicators in HDP patients was analyzed. Results: The relative expression levels of miR-181b, miR-210, IL-1β, IL-6, IL-17, TNF-α, MCP-1, and VCAM-1 in the observation group were higher than those in the control group (P<0.05). The relative expression level of miR-126 and IL-10 in the observation group were lower than those in the control group (P<0.05). In the GH group, the relative expression levels of miR-181b, miR-210, IL-1β, IL-6, IL-17, TNF-α, MCP-1, and VCAM-1 were lower than those in the MP and SP groups, and the MP group was lower than the SP group (P<0.05). The relative expression level of miR-126 and IL-10 in the GH group were higher than those in the MP and SP groups, and the MP group was higher than the SP group (P<0.05). Pearson correlation analysis showed that the relative expression levels of miR-181b, miR-210 in HDP patients were positively correlated with IL-1β, IL-6, IL-17, TNF-α, MCP-1, and VCAM-1, and negatively correlated with IL-10 (P<0.05). The relative expression level of miR-126 in HDP patients was negatively correlated with IL-1β, IL-6, IL-17, TNF-α, MCP-1, and VCAM-1, and positively correlated with IL-10 (P<0.05). Conclusion: miR-181b, miR-210 are highly expressed, and miR-126 is lowly expressed in HDP. All three are closely related to the inflammatory response in HDP.

Key words： Hypertensive disorders in pregnancy MicrornA-181b MicrornA-210 MicrornA-126

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2024.01.029 OR http://www.hbyxzzs.cn/EN/Y2024/V30/I1/147

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