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| Diagnostic Value of Blood Viscosity Reticulated Platelets and Platelet Parameters in Elderly Immune Thrombocytopenia |
| YANG Qiuting, ZHU Yanjun, FAN Yongli |
| Chengde Traditional Chinese Medicine, Hebei Chengde 067000, China |
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Abstract Objective: To explore the diagnostic value of blood viscosity, reticulated platelets, and platelet parameters in elderly patients with immune thrombocytopenia (ITP). Methods: A total of 82 elderly (age 60 and above) ITP patients from our hospital between 2020 and 2022 were included as the observation group. The control group included 50 elderly patients with non-immune thrombocytopenia (NITP) (25 cases with cirrhosis, 15 cases with hematological diseases, and 10 cases with other tumors). Another 50 elderly health examination participants were included as the second control group. Blood samples were collected for blood rheology analysis, including blood viscosity using a hemorheology analyzer, and platelet parameters [platelet distribution width (PDW), mean platelet volume (MPV), platelet-large cell ratio (P-LCR)] using an automated hematology analyzer. Comparative analysis of blood viscosity, reticulated platelets, PDW, MPV, and P-LCR before and after treatment was performed. Results: Before treatment, the observation group showed higher PDW, MPV, and reticulated platelet ratio compared to both control groups, while blood viscosity was lower, with statistical significance (P<0.05). There was no significant difference between Control Group 1 and Control Group 2 (P>0.05). As the platelet count decreased in the observation group, PDW and MPV increased, and blood viscosity decreased, showing statistically significant differences between the observation group and the control groups (P<0.05). Comparative analysis before and after treatment showed that in the observation group, the blood viscosity and platelet count of severe and mild-to-moderate patients increased after treatment (P<0.05), while reticulated platelets, P-LCR, PDW, and MPV significantly decreased and were lower than before treatment, with statistical significance (P<0.05). Conclusion: Determining blood viscosity, reticulated platelets, and platelet parameters significantly contributes to the etiological diagnosis and disease assessment of elderly ITP patients. Additionally, it plays a positive role in prognosis evaluation, providing ample diagnostic support for clinical practice.
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[1] 宋辉,孔飞飞,刘旋,等.网织血小板及其相关参数在儿童免疫性血小板减少症及脓毒症中的应用[J].检验医学,2018,33(7):626-628.
[2] Kohli R,Chaturvedi S.Epidemiology and clinical manifestations of immune thrombocytopenia[J].Hamostaseologie,2019,39(3): 238-249.
[3] Provan D,Arnold DM,Bussel JB,et al.Updated international consensus report on the investigation and management of primary immune thrombocytopenia[J].Blood Adv,2019,3(22):3780-3817.
[4] Mahabir VK,Ross C,Popovic S,et al.A blinded study of bone marrow examinations in patients with primary immune thrombocytopenia[J].Eur Haematol,2013,90(2):121-126.
[5] 隋青青.血细胞分析仪检测网织血小板诊断血液相关疾病的价值[J].中国医药指南,2021,19(9):120-121.
[6] 施展,邓姝,葛杭萍.原发免疫性血小板减少症并发血栓性血小板减少性紫癜1例[J].浙江实用医学,2021,26(4):347-350.
[7] 伞玉双,申静枝,方美云.原发免疫性血小板减少症糖皮质激素抵抗的临床因素分析[J].临床血液学杂志,2022,35(7):522-525.
[8] 谭建军.胎盘多肽治疗原发免疫性血小板减少症的临床研究[J].实用医院临床杂志,2018,15(5):110-113.
[9] 蔡薇,王芳婷,马亮亮.伴JAK3基因突变的普通变异型免疫缺陷病1例[J].中华血液学杂志,2022,43(1):79.
[10] 王丹微,杨平,沈瀚.网织血小板检测在免疫因素相关的血小板减少性疾病中的诊断价值[J].国际检验医学杂志.2017,38(18):2611-2613.
[11] 李琦,范凌,佟长青,等.环孢素治疗难治性自身免疫性血液病的效果及对白细胞介素17A、白细胞介素21水平的影响[J].中国医院用药评价与分析,2019,19(6):693-695. |
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2024, Vol. 30 
