多因子降维法分析MTHFR C677T基因多态性-Hcy交互作用对高血压合并冠心病的影响

doi:10.3969/j.issn.1006-6233.2024.01.012

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Abstract Objective: To analyze the effect of methylene tetrahydrofolate reductase (MTHFR) C677T gene polymorphism-Hcy interaction on hypertension combined with coronary heart disease based on multifactor dimension reduction (GMDR). Methods: A total of 150 hypertensive patients admitted to our hospital from March 2021 to October 2022 were selected as the study subjects. Based on coronary angiography results, they were divided into the isolated hypertension group (n=51) and the hypertension complicated with coronary heart disease group (n=99). General information, Hcy levels, and MTHFR C677T gene polymorphism distribution were compared between the two groups. Logistic regression analysis was used to identify factors influencing hypertension complicated with coronary heart disease, and GMDR was employed to analyze the interaction between MTHFR C677T gene polymorphism and Hcy. Results: There was no statistically significant difference between the observed and theoretical values of MTHFR C677T genotypic frequencies in the two groups (P>0.05). The duration of hypertension, Hcy, LDL-C, MTHFR C677T genotypes (TT), and the T allele were identified as influencing factors for hypertension complicated with coronary heart disease (P<0.05). GMDR results showed that the TT genotype of MTHFR C677T in interaction with Hcy formed the optimal model for the risk of hypertension complicated with coronary heart disease. The cross-validation consistency was 10/10, the testing accuracy was 75.00%, and the sign test P-value was 0.011. Conclusion: MTHFR C677T gene polymorphism and the interaction with Hcy may increase the risk of coronary heart disease. Clinicians should dynamically monitor changes in these indicators and take effective treatment measures promptly to reduce the occurrence of coronary heart disease.

Key words： Hypertension Coronary heart disease Multi-factor dimensionality reduction method MTHFR C677T gene polymorphism Homocysteine

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	ZHANG Mingchao
	WANG Juan
	LU Dasheng
	et al

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ZHANG Mingchao,WANG Juan,LU Dasheng, et al. Analysis of the Impact of MTHFR C677T Gene Polymorphism-Hcy Interaction on Hypertension Complicated with Coronary Heart Disease Using Multifactor Dimensionality Reduction[J]. HeBei Med, 2024, 30(1): 65-70.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2024.01.012 OR http://www.hbyxzzs.cn/EN/Y2024/V30/I1/65

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