外周血中miR-34b表达水平对Ⅲb~Ⅳ期NSCLC患者靶向治疗效果及预后的评估价值分析

doi:10.3969/j.issn.1006-6233.2024.01.08

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Abstract Objective: To explore the evaluation value of peripheral blood microRNA-34b (miR-34b) for targeted therapy effect and prognosis in patients with stage Ⅲb-Ⅳ non-small cell lung cancer (NSCLC). Methods: A total of 104 NSCLC patients who received targeted treatment from January 2020 to January 2022 were selected. According to the efficacy of targeted treatment, they were divided into the effective group (n=40) and ineffective group (n=64). All patients were followed up for one year, and based on the prognosis, they were divided into the survival group (n=32) and death group (n=72). Real-time quantitative PCR was used to detect miR-34b in peripheral blood. The receiver operating characteristic curve (ROC) was employed to analyze the evaluation value of peripheral blood miR-34b expression level for the targeted treatment effect and prognosis of stage Ⅲb-Ⅳ NSCLC patients. Kaplan-Meier survival curve analysis was used to explore the relationship between different peripheral blood miR-34b expression levels and the prognosis of stage Ⅲb-Ⅳ NSCLC patients. Results: The peripheral blood miR-34b expression level in the effective group was higher than that in the ineffective group (P<0.05). The ROC curve showed that the AUC of peripheral blood miR-34b expression level in evaluating the targeted treatment effect of stage Ⅲb-Ⅳ NSCLC patients was 0.856 (P<0.05). The peripheral blood miR-34b expression level in the survival group was higher than that in the death group (P<0.05). The ROC curve showed that the AUC of peripheral blood miR-34b expression level in evaluating the prognosis of stage Ⅲb-Ⅳ NSCLC patients was 0.916 (P<0.05). The Log-rank test showed a statistically significant difference in survival rate between the miR-34b > 2.16 group and miR-34b ≤ 2.16 group (P<0.05). Conclusion: The expression level of peripheral blood miR-34b is associated with the targeted treatment effect and prognosis of stage Ⅲb-Ⅳ NSCLC patients. Detecting the expression level of peripheral blood miR-34b is helpful for evaluating the targeted treatment effect and prognosis.

Key words： Non-small cell lung cancer miRNA-34b Targeted treatment

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2024.01.08 OR http://www.hbyxzzs.cn/EN/Y2024/V30/I1/45

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