T2DM伴慢性牙周炎患者龈沟液中hBD-2 hBD-3 LPS与牙周健康指标的关系

doi:10.3969/j.issn.1006-6233.2023.12.016

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Abstract Objective: To explore changes in β-defensins (hBD-2, hBD-3), lipopolysaccharides (LPS) in gingival crevicular fluid (GCF), and their correlation with periodontal health indicators in patients with type 2 diabetes mellitus (T2DM) and chronic periodontitis. Methods: This study, approved by the Medical Ethics Committee, included 120 patients diagnosed with T2DM and chronic periodontitis (Group A), 120 chronic periodontitis patients without T2DM (Group B), and 120 periodontally healthy individuals without T2DM (Group C), between January 2020 and December 2022. GCF levels of hBD-2, hBD-3, LPS, oral and periodontal health-related indicators, and subgingival bacterial flora were measured. The correlation between hBD-2, hBD-3, LPS, and periodontal health indicators in T2DM patients with chronic periodontitis was analyzed. Results: The GCF levels of hBD-2, hBD-3, and LPS in Groups A, B, and C showed significant differences (P<0.05). In Group A, hBD-2, hBD-3 were lower than in Groups B and C, while LPS was higher than in Groups B and C. Group B had lower hBD-2, hBD-3 compared to Group C, and higher LPS than Group C (P<0.05). Periodontal parameters including PD, SBI, CAL, GCF in Groups A, B, and C showed significant differences (P<0.05). Group A had higher values than Groups B and C, and Group B had higher values than Group C (P<0.05). The levels of Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Prevotella intermedia, and Tannerella forsythia in Groups A, B, and C differed significantly (P<0.05). Group A had higher levels compared to Groups B and C, and Group B had higher levels compared to Group C (P<0.05). Significant negative correlations were found between GCF hBD-2, hBD-3, and PD, SBI, CAL, GCF, while LPS showed a significant positive correlation with these parameters (P<0.05). Conclusion: GCF levels of hBD-2, hBD-3 significantly decrease, and LPS significantly increase in T2DM patients with chronic periodontitis, showing a close relationship with the deterioration of periodontal health indicators.

Key words： Type 2 diabetes mellitus Chronic periodontitis Gingival crevicular fluid β-defensins Lipopolysaccharides Periodontal health indicators Microbial flora

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	Articles by authors
	HAILIDA Makexi
	YANG Fang
	AIKEREMU Musha

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HAILIDA Makexi,YANG Fang,AIKEREMU Musha. Relationship between Gingival Crevicular Fluid Levels of hBD-2 hBD-3 LPS and Periodontal Health Indicators in Patients with Type 2 Diabetes Mellitus and Chronic Periodontitis[J]. HeBei Med, 2023, 29(12): 2023-2027.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2023.12.016 OR http://www.hbyxzzs.cn/EN/Y2023/V29/I12/2023

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