阿仑膦酸钠在骨质疏松椎体压缩性骨折椎体成形术后应用价值

doi:10.3969/j.issn.1006-6233.2023.12.012

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Abstract Objective: To investigate the role of alendronate anti-osteoporosis in fracture healing and prevention of re-fracture after vertebroplasty for osteoporotic vertebral compression fracture (OVCF). Methods: A total of 99 patients with OVCF who underwent PVP in our hospital from August 2021 to August 2022 were selected and randomly divided into control group (49 cases) and study group (50 cases). The control group was given basic anti-osteoporosis intervention after surgery, and the study group was given new generation bisphosphonate on the basis of the control group after surgery. The treatment continued 6 months. Postoperative rehabilitation, pain level (VAS score), lumbar spine function (ODI score, JOA score), bone mineral density, bone turnover indexes [N-terminal mid-portion osteocalcin (N-MID-OT), β-collagen special sequence (β-CTX), and total type 1 collagen amino-terminal prolongation peptide (T-P1NP)], vertebral stability indexes (height ratio of the injured vertebrae, Cobb's angle of the injured vertebrae), and incidence of re-fracture were compared in the two groups were compared. Results: The fracture healing time and recovery time of the study group were shorter than those of the control group (P<0.05). After 3 and 6 months of treatment, VAS, ODI scores and Cobb Angle of injured vertebra in the study group were lower than those in the control group, while JOA scores, height ratio of injured vertebra, Ward triangle and bone density of femoral neck in the study group were higher than those in the control group (P<0.05). The serum levels of N-MID-OT, β-CTX and T-P1NP in the study group were lower than those in the control group after 1 month, 3 months and 6 months of treatment (P<0.05). The incidence of refracture in the study group was lower than that in the control group (P<0.05). Conclusion: Alendronate combined with PVP in the treatment of OVCF improves bone metabolism, promotes fracture healing, reduces the incidence of postoperative re-fracture, and has significant advantages in the recovery of patients' lumbar spine function and pain relief.

Key words： Alendronate sodium Osteoporotic vertebral compression fracture Vertebroplasty Fracture union Refracture

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	LIAO Dan
	QIAN Li

Cite this article:

LIAO Dan,QIAN Li. The Value of Alendronate after OVCF Vertebroplasty[J]. HeBei Med, 2023, 29(12): 1998-2004.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2023.12.012 OR http://www.hbyxzzs.cn/EN/Y2023/V29/I12/1998

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