RDW hs-CRP 凝血纤溶指标与缺血性脑卒中患者脑动脉狭窄的相关性分析

doi:10.3969/j.issn.1006-6233.2023.11.020

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Abstract Objective: To analyze the correlation between Red Blood Cell Distribution Width (RDW),high-sensitivity C-reactive protein (hs-CRP),and coagulation-fibrinolysis index with cerebral artery stenosis in patients suffering from ischemic stroke. Methods: A total of 126 patients with cerebral arterial thrombosis admitted to our hospital between January 2019 and May 2021 were included.They were categorized into two groups:the cerebral arterial stenosis group (n=57) and the cerebral arterial normal group (n=69) based on the presence of cerebral artery stenosis.Comparative analysis of RDW,high-sensitivity C-reactive protein (hs-CRP),and coagulation-fibrinolysis index was performed between the two groups,and their correlations were examined. Results: Significant differences were observed in the history of hypertension between the two groups of patients (P<0.05).In the cerebral arterial stenosis group,patients exhibited significantly larger red blood cell distribution width (RDW) values in the neck region compared to the cerebral arterial normal group (P<0.05).Additionally,hs-CRP levels in the cerebral arterial stenosis group were notably higher than those in the cerebral arterial normal group,with statistically significant differences (P<0.05).Furthermore,patients in the cerebral arterial stenosis group had significantly lower levels of activated partial thromboplastin time (APTT) compared to patients in the cerebral arterial normal group (P<0.05).In contrast,fibrinogen (FIB) and D-dimer (D-D) levels in the cerebral arterial stenosis group were significantly higher than those in the cerebral arterial normal group (P<0.05).Pearson or spearman correlation analysis results demonstrated a significant positive correlation between RDW,FIB,D-D,hs-CRP,and cerebral artery stenosis (P<0.05).However,APTT showed a significant negative correlation with cerebral artery stenosis (P<0.05). Conclusion: The findings suggest that RDW,hs-CRP,and coagulation-fibrinolysis index are indeed correlated with cerebral artery stenosis in patients with cerebral arterial thrombosis.

Key words： Red blood cell distribution width hs-CRP Coagulation and fibrinolysis indexes Ischemic stroke Cerebral arterial stenosis

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2023.11.020 OR http://www.hbyxzzs.cn/EN/Y2023/V29/I11/1864

[1] Wang L,Xiong X,Zhang L,et al.Neurovascular unit:a critical role in ischemic stroke[J].CNS Neurosci Ther,2021,27(1):7-16.
[2] 杨逸昊,陆靖,童婧怡,等.急性缺血性脑卒中后自发性出血转化风险预测研究的进展[J].中华神经医学杂志,2023,22(4):414-417.
[3] 王春慧,李友凤,胡睿瑶,等.红细胞分布宽度与血小板计数比值对急性缺血性脑卒中短期预后的影响[J].中风与神经疾病杂志,2020,37(4):337-340.
[4] 王清莲,赵海涛.宫氏脑针对缺血性脑卒中患者神经功能及凝血纤溶指标的影响[J].血栓与止血学,2022,28(3):741-742.
[5] 周琦,柯玲,阮科,等.系统炎症因子预测老年冠心病PCI术后主要不良心脑血管事件的价值[J].临床心血管病杂志,2022,38(2):118-123.
[6] 李秀娟,余珊,苏剑辉,等.急性缺血性卒中患者在院期间红细胞分布宽度波动与预后相关性研究[J].临床军医杂志,2023,51(6):635-637.
[7] 杨勇涛,鲍娟,曹毅,等.急性缺血性脑卒中血管内治疗21例临床分析[J].国际神经病学神经外科学杂志,2020,47(2):15-20.
[8] Hong RH,Zhu J,Li ZZ,et al.Red blood cell distribution width is associated with neuronal damage in acute ischemic stroke[J].Aging,2020,12(10):9855-9867.
[9] Hong L,Fang K,Ling Y,et al.Red blood cell distribution width is associated with collateral flow and final infarct volume in acute stroke with large artery atherosclerosis[J].Semin Thromb Hemost,2020,46(4):502-506.
[10] 李丹丹,梅俊,周庆兵,等.固有免疫介导的炎症反应在动脉粥样硬化发病机制中的研究进展[J].中国动脉硬化杂志,2022,30(1):71-76.
[11] 李寅珍,张晶文,郑永强.血清Hcy、hs-CRP、CysC水平在缺血性脑卒中患者脑微出血发生及预后中的应用[J].中国老年学杂志,2023,43(4):798-802.
[12] 马新,鲜晓莉,柴树红.红细胞分布宽度与血小板比值、D-二聚体与纤维蛋白原比值评估急性缺血性脑卒中短期预后的临床价值[J].重庆医学,2022,51(23):3997-4003.
[13] 邓俊国,孟令秀,熊爱红,等.脑卒中合并冠心病患者PCI中应用不同剂量比伐卢定对PLT、MPV及FIB的影响[J].分子诊断与治疗杂志,2022,14(8):1346-1349.