|
|
|
| Expression and Survival Analysis of C1q-Like Protein 4 in Breast Cancer |
| ZHANG Qing, FANG Haotian, LI Qingshan, et al |
| The Affiliated Hospital of Chengde Medical University, Hebei Chengde 067000, China |
|
|
|
|
Abstract Objective: To investigate the expression of C1ql4 in breast cancer patients,and to analyze the relationship between C1ql4 and relevant clinicopathological features and prognosis of breast cancer. Methods: The study examined the expression of C1ql4 protein using immunohistochemistry in 143 breast cancer patients,with 20 breast fibroadenoma tissues serving as controls.Clinical and pathological data were collected,and the survival and prognosis of patients were monitored.The association between C1ql4 expression and prognosis was analyzed using Kaplan-Meier survival curves and multivariate Cox regression.Differences were considered statistically significant at P<0.05. Results: The positive expression rate of C1ql4 protein was 15% (3/20) in breast fibroadenoma and 98.6% (141/143) in breast cancer.In breast cancer tissues,C1ql4 low expression was observed in 47.6% (68/143) of cases,while high expression was found in 51.0% (73/143) of cases.C1ql4 expression was associated with various clinical factors,including tumor diameter,lymph node metastasis,TNM stage,and molecular subtypes (P<0.05).Patients in the high expression group of C1ql4 had a worse prognosis (P<0.05).Multivariate Cox regression analysis demonstrated that TNM stage,molecular subtyping,and high C1ql4 expression were independent risk factors for an unfavorable prognosis in breast cancer patients (P<0.05). Conclusion: C1ql4 is highly expressed in breast cancer tissues and is associated with prognosis and adverse pathological parameters.
|
|
|
|
|
|
[1] S-C Houghton,Hankinson S-E.Cancer progress and priorities:breast cancer[J].Cancer Epidemiol Biomarkers Prev,2021,30(5):822-844.
[2] K-D Miller,Nogueira L,Devasia T,et al.Cancer treatment and survivorship statistics,2022[J].CA Cancer Clin,2022,72(5):409-436.
[3] A Tan,Ke S,Chen Y,et al.Expression patterns of C1ql4 and its cell-adhesion GPCR Bai3 in the murine testis and functional roles in steroidogenesis[J].FASEB,2019,33(4):4893-4906.
[4] N Hamoud,Tran V,Aimi T,et al.Spatiotemporal regulation of the GPCR activity of BAI3 by C1qL4 and Stabilin-2 controls myoblast fusion[J].Nat Commun,2018,9(1):4470.
[5] T Li,Kang G,Wang T,et al.Tumor angiogenesis and anti-angiogenic gene therapy for cancer[J].Oncol Lett,2018,16(1):687-702.
[6] X Zhou,Ding X,Li H,et al.Upregulation of TIGIT and PD-1 in colorectal cancer with mismatch-repair deficiency[J].Immunol Invest,2021,50(4):338-355.
[7] F Cardoso,Paluch-Shimon S,Senkus E,et al.5th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 5)[J].Ann Oncol,2020,31(12):1623-1649.
[8] E-C de Heer,Jalving M,Harris A-L.HIFs,angiogenesis,and metabolism:elusive enemies in breast cancer[J].Clin Invest,2020,130(10):5074-5087. |
|
|
|
2023, Vol. 29 
