|
|
|
| Correlation between KRT17 and KLF4 Expression in Cervical Cancer Tissue and Patient Prognosis |
| CHANG Chang, GAO Jing, LI Zhiqiang |
| The Second Hospital Affiliated to Hebei North College, Hebei Zhangjiakou 075100, China |
|
|
|
|
Abstract Objective: To investigate the correlation between the expression of Keratin 17 (KRT17) and Kruppel-like factor 4 (KLF4) in cervical cancer (CC) tissue and the prognosis of patients. Methods: From April 2015 to April 2019,86 patients diagnosed with CC in the Department of Obstetrics and Gynecology at our hospital were included in this study.Tissue samples were collected from the cancerous areas (CC group) and adjacent non-cancerous areas (adjacent group).The expressions of KRT17 and KLF4 were assessed using immunohistochemistry.Kaplan-Meier analysis was employed to examine the relationship between KRT17,KLF4 expression,and the prognosis of CC patients.Additionally,COX regression analysis was conducted to identify risk factors influencing the prognosis of CC patients. Results: In comparison to the adjacent group,the CC group exhibited a significantly higher rate of positive KRT17 expression and a notably lower rate of positive KLF4 expression (P<0.05).The expression levels of KRT17 and KLF4 were found to be associated with the depth of myometrial invasion,lymph node metastasis,and the degree of differentiation (P<0.05).Kaplan-Meier analysis revealed that within the KRT17 high-expression group,patients had a lower 3-year cumulative survival rate compared to the low-expression group.Conversely,the 3-year cumulative survival rate in the KLF4 high-expression group was higher than in the low-expression group (P<0.05).Multivariate COX regression analysis demonstrated that myometrial invasion depth,lymph node metastasis,KRT17,and KLF4 expression were significant risk factors affecting the prognosis of CC patients (P<0.05). Conclusion: In the CC group,there was a significant increase in the rate of positive KRT17 expression and a significant decrease in the rate of positive KLF4 expression.These findings are closely related to clinicopathological characteristics and hold valuable implications for evaluating the prognosis of CC patients.
|
|
|
|
|
|
[1] 高辉,齐月,高雨.长链非编码RNATUSC8在宫颈癌中的表达及临床意义[J].广东医学,2020,41(17):1768-1772.
[2] 娄雪玲,张占薪,刘灵,等.宫颈癌患者癌组织和外周血Kruppel样因子的表达及其临床意义[J].中国实用医刊,2020,47(6):1-4.
[3] 宁佳羽,包伟晶,周素娟,等.LncRNA-MEG3和KLF4在鼻咽癌发生发展中的作用及可能机制[J].肿瘤防治研究,2021,48(3):234-238.
[4] 盛修贵,吴小华,吴令英,等.子宫颈癌诊断与治疗指南(2021年版)[J].中国癌症杂志,2021,31(6):16.
[5] 周晖,刘昀昀.《2020 NCCN子宫颈癌临床实践指南(第1版)》解读[J].中国实用妇科与产科杂志,2020,36(2):131-138.
[6] 王小燕,李虎玲,林丹丹,等.整合生物信息学分析筛选宫颈癌的关键预后生物标志物[J].新疆医科大学学报,2022,45(2):143-149,154.
[7] 刘佳琪,李朋飞.基于中国子宫颈癌临床诊疗大数据的子宫颈癌诊疗规范化调查分析[J].中国实用妇科与产科杂志,2021,37(1):82-86.
[8] 肖群,方燕飞,孔于兰.同步放化疗与单纯放疗对中晚期宫颈癌患者的有效性及安全性比较[J].中华全科医学,2022,16(11):1813-1815,1905.
[9] 黄畅,应沛汐,易果果,等.单细胞RNA测序在眼角膜和视网膜疾病诊断治疗中的应用[J].中国组织工程研究 2022,26(13):2106-2113.
[10] Liu HX,Li N,Wei L,et al.High expression of Kruppel-like factor 4 as a predictor of poor prognosis for cervical cancer patient response to radiotherapy[J].Tumour Biol,2017,39(6):1-9.
[11] 邓刚,蔡谭兴,雷钊,等.SALL4基因在肝内胆管癌中通过抑制KLF4基因表达促进EMT改变[J].肿瘤药学,2021,11(1):36-39. |
|
|
|
2023, Vol. 29 
