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Correlation between Serum HMGB1 and Inflammatory Indicators and Lung Function Parameters in Patients with Acute Exacerbation of COPD |
TANG Wenjun, ZENG Zhu, et al |
The Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Sichuan Chengdu 610072, China |
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Abstract Objective: To analyze the correlation of serum high mobility group protein 1 (HMGB1) with inflammatory indicators and pulmonary function parameters in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods: A total of 104 patients with AECOPD who were treated in the hospital from January 2020 to June 2022 were selected and included in AECOPD group, and another 104 patients with stable chronic obstructive pulmonary disease (COPD) were enrolled as COPD group. 104 healthy subjects with physical examination during the same time period were included in healthy control group. The levels of peripheral blood related indicators [HMGB1, hypoxia-inducible factor-1α (HIF-1α), white blood cell count (WBC)] and serum inflammatory factors [interleukin-6 (IL-6), C-reactive protein (CRP), procalcitonin (PCT)] and pulmonary function parameters [6-minute walk distance (6MWD), pulmonary artery pressure, partial pressure of carbon dioxide (PaCO2), partial pressure of oxygen (PaO2)] were compared among the groups at admission. The relationship between serum HMGB1 and the above inflammatory indicators and pulmonary function parameters was analyzed. Results: The levels of serum HMGB1, HIF-1α, IL-6, CRP, PCT and WBC in the three groups at admission were manifested as AECOPD group>COPD group> healthy control group (P<0.05). The 6MWD and PaO2 at admission were shown as AECOPD group<COPD group< healthy control group (P<0.05). The pulmonary artery pressure and PaCO2 of the three groups at admission showed AECOPD group>COPD group>healthy control group (P<0.05). Pearson correlation analysis showed that serum HMGB1 level at admission was positively correlated with IL-6, CRP and pulmonary artery pressure in patients with AECOPD (r=0.566, 0.287, 0.230, all P<0.05), and was negatively correlated with PaO2 (r=-0.212, P<0.05). Conclusion: Compared with patients with stable COPD and healthy subjects, serum HMGB1 level in patients with AECOPD is abnormally increased, and serum HMGB1 is closely related to IL-6, CRP, pulmonary artery pressure and PaO2.
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