老年射血分数保留型心衰合并衰弱的临床特征及NT-proBNP超声心动图参数变化的临床意义

doi:10.3969/j.issn.1006-6233.2023.09.013

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Abstract Objective: To analyze characteristics in elderly patients with heart failure with preserved ejection fraction (HFpEF) and frailty, and to explore the clinical significance of peripheral blood N-terminal pro-B-type natriuretic peptide (NT-proBNP) and echocardiogram parameters. Methods: A total of 96 patients with HFpEF admitted to the hospital were enrolled between February 2021 and February 2023. The frailty was evaluated by Fried Frailty Evaluation Criteria within 24h after admission. According to the evaluation results, patients were divided into frailty group (n=56) and non-frailty group (n=40). The clinical data in the two groups were collected. The risk factors of frailty were analyzed by univariate analysis and multivariate Logsitic regression analysis. Results: Compared with non-frailty group, the age, proportion of NYHA grading at grade III/IV, proportion of nutritional risk and NT-proBNP level in frailty group were higher (P<0.05), while levels of hemoglobin (Hb) and albumin (ALB) were lower (P<0.05). The left ventricular ejection fraction (LVEF) in frailty group was lower (P<0.05), while left ventricular end-diastolic diameter (LVDD), left ventricular end-systolic diameter (LVDS) aortic diameter (AOD) were longer or larger (P<0.05). There was no significant difference in left atrial diameter (LVDS) or left ventricular posterior wall thickness (LVPW) between the two groups (P>0.05). Multivariate Logistic regression showed advanced age, NYHA grading at grade III/IV, high-level NT-proBNP and widened AOD were independent risk factors of frailty in elderly patients with HFpEF (P<0.05). Conclusion: Elderly patients with HFpEF have high incidence of frailty. Advanced age, NYHA grading at grade III/IV, high-level NT-proBNP, and widened AOD are independent risk factors of frailty.

Key words： Elderly Heart failure Ejection fraction preservation Frailty Clinical characteristic Ultrasound

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2023.09.013 OR http://www.hbyxzzs.cn/EN/Y2023/V29/I9/1479

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