血清miR-499联合PLTP水平对不停跳冠状动脉旁路移植术后心房颤动的预测价值

doi:10.3969/j.issn.1006-6233.2023.08.012

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Abstract Objective: To investigate the predictive value of serum microRNA-499 (miR-499) combined with phospholipid transfer protein (PLTP) levels on atrial fibrillation (AF) after off-pump isolated coronary artery bypass grafting (OPCABG). Methods: A total of 237 patients with coronary artery disease who underwent OPCABG admitted to our hospital from January 2018 to June 2022 were selected and divided into 69 cases in the AF group and 168 cases in the non-AF group according to whether AF occurred after OPCABG.Serum miR-499 and PLTP levels were measured by qPCR and ELISA.Spearman correlation was used to analyze the correlation between serum miR-499 and PLTP levels in patients with AF after OPCABG,multi-factor logistic regression was used to analyze the factors influencing AF after OPCABG,and ROC curve was used to analyze the predictive value of serum miR-499 and PLTP levels on AF after OPCABG. Results: Serum miR-499 levels were higher in the AF group (1.53±0.29) than in the non-AF group (1.22±0.33),and PLTP levels[1.36 (1.00,2.01)] were lower than in the non-AF group[2.33 (1.39,3.53)],with statistically significant differences (t/Z=6.731,5.879,all P<0.001).Spearman correlation analysis showed that serum miR-499 was negatively correlated with PLTP levels in AF patients after OPCABG (rs=-0.789,P<0.001).Multifactorial logistic regression analysis showed that age (OR=1.085,95% CI:1.036 to 1.136),diabetes (OR=3.399,95% CI:1.472 to 7.853),left atrial diameter (OR=1.194,95% CI:1.063 to 1.341) and miR-499 (OR=2.961,95% CI:1.944 to 4.508) were independent risk factors for AF after OPCABG and PLTP (OR=0.319,95% CI:0.195 to 0.522) was an independent protective factor (P<0.05).ROC curve analysis showed that serum miR-499 combined with PLTP levels (AUC=0.842,95% CI:0.789 to 0.886) predicted a greater AUC for AF after OPCABG than miR-499 (AUC=0.759,95% CI:0.699 to 0.812),PLTP (AUC=0.743,95% CI:0.683 to 0.798) predicted individually (Z=3.154,3.804,all P<0.05). Conclusion: Increased serum miR-499 levels and decreased PLTP levels were independently associated with post-OPCABG AF,and serum miR-499 combined with PLTP levels were of high value in predicting post-OPCABG AF.

Key words： Off-pump isolated coronary artery bypass grafting MicroRNA-499 Phospholipid transfer protein Atrial fibrillation Prediction

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2023.08.012 OR http://www.hbyxzzs.cn/EN/Y2023/V29/I8/1292

[1] 中国心血管健康与疾病报告编写组.中国心血管健康与疾病报告2021概要[J].心脑血管病防治,2022,22(4):20-36,40.
[2] 复杂冠心病血运重建心脏团队决策研究协作组.复杂冠心病血运重建策略内外科专家共识[J].中国循环杂志,2022,37(11):1073-1085.
[3] 李艳茹,张琼,瞿晓雅,等.心房颤动电重构机制中相关microRNA的表达差异[J].徐州医学院学报,2016,36(5):291-295.
[4] 刘力黎,陈诚,张丽敏.血脂水平与心房颤动相关性研究进展[J].心血管病学进展,2021,42(6):539-542.
[5] Jiang XC,Yu Y.The Role of Phospholipid transfer protein in the development of atherosclerosis[J].Curr Atheroscler Rep,2021,23(3):9.
[6] Li XY,Hou HT,Chen HX,et al.Preoperative plasma biomarkers associated with atrial fibrillation after coronary artery bypass surgery[J].Thorac Cardiovasc Surg,2021,162(3):851-863.
[7] 颜红兵.临床冠心病诊断与治疗指南[M].北京:人民卫生出版社,2010.5-26.
[8] Kirchhof P,Benussi S,Kotecha D,et al.2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS[J].Eur Heart,2016,37(38):2893-2962.
[9] Zhou R,Huang W,Fan X,et al.miR-499 released during myocardial infarction causes endothelial injury by targeting α7-nAchR[J].Cell Mol Med,2019,23(9):6085-6097.
[10] Ling TY,Wang XL,Chai Q,et al.Regulation of the SK3 channel by microRNA-499-potential role in atrial fibrillation[J].Heart Rhythm,2013,10(7):1001-1009.
[11] 中华医学会心电生理和起搏分会,中国医师协会心律学专业委员会,中国房颤中心联盟心房颤动防治专家工作委员会.心房颤动:目前的认识和治疗建议(2021)[J].中华心律失常学杂志,2022,26(1):15-88.
[12] Ling TY,Wang XL,Chai Q,et al.Regulation of cardiac CACNB2 by microRNA-499:Potential role in atrial fibrillation[J].BBA Clin,2017,2(7):78-84.
[13] Jiang XC,Yu Y.The Role of Phospholipid transfer protein in the development of atherosclerosis[J].Curr Atheroscler Rep,2021,23(3):9.
[14] Zhang M,Zhai X,Li J,et al.Structural basis of the lipid transfer mechanism of phospholipid transfer protein (PLTP)[J].Biochim Biophys Acta Mol Cell Biol Lipids,2018,1863(9):1082-1094.