环状软骨上喉部分切除术与全喉切除术对中晚期喉癌患者血清let-7a CK18水平及无瘤生存期的影响对比

doi:10.3969/j.issn.1006-6233.2023.07.020

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Abstract Objective: To compare the effects of supracricoid partial laryngectomy and total laryngectomy on patients with advanced laryngeal cancer. Methods: A total of 105 patients with advanced laryngeal cancer in the hospital from February 2016 to June 2019 were selected as the research subjects,and they were classified into control group (n=50) and observation group (n=55) by means of different surgical regimens.The control group underwent total laryngectomy while the observation group received supracricoid partial laryngectomy.The patients were followed up for 3 years after surgery.The perioperative indicators[postoperative drainage volume,nasal feeding time,trial eating start time,hospital stay],postoperative complications,levels of serum let-7a and CK18 before and after surgery,swallowing function and tumor-free survival were compared between groups of patients. Results: The various perioperative indicators in observation group were better than those in control group (P<0.05).The total incidence rate of complications in observation group at 7 days after surgery was lower compared with that in control group (P<0.05).The swallowing function grading in observation group was better compared to control group (P<0.05).After surgery,the level of serum let-7a in observation group was higher (P<0.05) while the CK18 was lower than that in control group (P<0.05).There was no statistical difference in the 3-year overall survival rate between both groups (P>0.05). Conclusion: Supracricoid partial laryngectomy in the treatment of patients with advanced laryngeal cancer can significantly improve the perioperative indicators,serum indicators and swallowing function.In addition,it has few complications and its long-term prognosis is comparable to that of total laryngectomy.

Key words： Supracricoid partial laryngectomy Total laryngectomy Advanced laryngeal cancer Tumor-free survival

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	LI Zhiyong
	YANG Quanquan
	MA Peng
	et al

Cite this article:

LI Zhiyong,YANG Quanquan,MA Peng, et al. Comparison of Effects of Supracricoid Partial Laryngectomy and Total Laryngectomy on Serum let-7a and CK18 Levels and Tumor-Free Survival in Patients with Advanced Laryngeal Ccancer[J]. HeBei Med, 2023, 29(7): 1164-1168.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2023.07.020 OR http://www.hbyxzzs.cn/EN/Y2023/V29/I7/1164

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