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| Effect of Different Doses of Remazolam on Cardiovascular Responses during Induction of General Anesthesia in Patients Undergoing Laparoscopic Cholecystectomy |
| WU Xuan, ZHOU Maojing, HU Wenju |
| Huainan Xinhua Hospital, Anhui University of Science and Technology, Anhui Huainan 232052, China |
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Abstract Objective: To observe the effects of different doses of Remazolam on cardiovascular responses in patients undergoing laparoscopic cholecystectomy under general anesthesia. Methods: A total of 122 patients who underwent laparoscopic cholecystectomy in our hospital from January 2021 to February 2022 were prospectively selected and divided into two groups according to the random number table generated by statistical software using a simple random design scheme. The control group was anesthetised with 0.1 mg/kg remazolam, and the observation group was anesthetised with 0.2 mg/kg Remazolam. The differences of hemodynamics between the two groups were detected, and anesthesia and adverse reactions were compared between the two groups. Results: There was no significant difference in blood glucose level between the two groups at T0 (P>0.05). When the blood glucose level of the two groups was higher than T0 at 1 min (T1) and 5 min (T2) after anesthesia intubation, the blood glucose level of the observation group at T1 and T2 was lower than that of the control group (P<0.05). At T0, there was no significant difference in hemodynamics between the two groups (P>0.05). The heart rate (HR) and mean arterial pressure (MAP) levels of the control group were higher at T1 and T2 than at T0 (P<0.05). The levels of HR and MAP in the observation group at T1 were higher than those at T0, but there was no statistical difference between the levels of HR and MAP at T2 and those at T0 (P>0.05). The levels of HR and MAP in the observation group at T1 and T2 were lower than those in the control group (P<0.05). The onset time of anesthesia and the duration of PACU in the observation group were shorter than those in the control group, while the recovery time and extubation time had no statistical difference (P>0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: In laparoscopic cholecystectomy, 0.2mg/kg Remazolam for anesthesia induction can stabilize blood flow.
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[1] 严小鹏,张苗苗,张东,等.磁锚定经脐单孔腹腔镜胆囊切除术的临床应用研究[J].中华外科杂志,2022,60(6):618-621.
[2] 赵刚,张朝阳,乔师师,等.胆囊后三角入路与胆囊前三角入路腹腔镜胆囊切除术治疗胆囊结石伴慢性胆囊炎疗效比较[J].新乡医学院学报,2020,37(6):535-539.
[3] 陈瑜,蔡姝,朱晓刚,等.瑞马唑仑用于老年患者全麻诱导时的镇静效果[J].中华麻醉学杂志,2020,40(8):974-976.
[4] 郭之瑜,姚玉凤.上海市嘉定区江桥镇老年体检胆囊疾病流行特征及危险因素的相关分析[J].山西医药杂志,2020,49(16):2095-2098.
[5] Cassinotti,Elisa,Baldari,et al.Laparoscopic cholecystectomy in the cirrhotic:review of literature on indications and technique[J].The American Journal of Gastroenterology,2020,115(2):208-212.
[6] 钱焕丽,李元海,何川,等.瑞马唑仑与咪达唑仑对全身麻醉下行腹腔镜胆囊切除术患者术后认知功能影响的对比研究[J].河北医科大学学报,2021,42(6):704-707,712.
[7] 余婉秋,李禹琼,朱圣姬,等.苯磺酸瑞马唑仑与丙泊酚用于无痛结肠镜检查的有效性及安全性的随机、单盲、平行对照研究[J].贵州医药,2020,44(6):846-849.
[8] Marthe Chehade,Benedict Kakala,et al.Intraoperative detection of aberrant biliary anatomy via intraoperative cholangiography during laparoscopic cholecystectomy[J].ANZ journal of surgery,2019,89(7/8):889-894.
[9] Kamarajah,Sivesh K.,Karri,et al.Perioperative outcomes after laparoscopic cholecystectomy in elderly patients:a systematic review and meta-analysis[J].Surgical Endoscopy,2020,34(11):4727-4740.
[10] 管忍,董希玮,马宁,等.基于计算机模拟概述创新性软药瑞马唑仑[J].国际麻醉学与复苏杂志,2020,41(10):946-954. |
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2023, Vol. 29 
