富血小板纤维蛋白与Bio-Oss骨粉在上颌窦底外提升术中应用价值对比研究

doi:10.3969/j.issn.1006-6233.2023.06.021

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Abstract Objective: To investigate the clinical value of platelet-rich fibrin (PRF) and Bio-Oss bone meal in the clinical value of extra-maxillary sinus lift surgery. Methods: A total of 120 patients who were treated in our hospital from July 2020 to January 2021 and received extra-maxillary sinus lift surgery were selected and simply randomly divided into 58 patients in PRF group and 62 patients in Bio-Oss group by random number table method, with platelet-rich fibrin (PRF) implantation intervention procedure in PRF group and Bio-Oss bone powder implantation intervention procedure in Bio-Oss group. Pain, mucosa at the surgical site, postoperative bone defect regeneration and surrounding soft tissue health were observed in the two groups, bone density changes, platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), transforming growth factor-β(TGF-β) index levels before and after treatment in both groups, Pearman analysis of bone density and PDGF, VEGF, TGF-β correlation was conducted. Results: Pain performance was significantly lower in the PRF group compared with the Bio-Oss group, the proportion of patients with normal mucosal color was significantly higher in the PRF group compared with the Bio-Oss group, and the degree of mucosal swelling was significantly lower compared with the Bio-Oss group; the levels of bleeding index, probing depth, and attachment loss index were significantly lower in the PRF group compared with the Bio-Oss group, and the bone graft height and osteogenic thickness index were significantly higher in the PRF group compared with the Bio-Oss group. Oss group (all P<0.05); BMD in both groups decreased significantly compared to the preoperative level 1 month after surgery, but the PRF group had a higher BMD level than the Bio-Oss group (P<0.05); BMD values in the Bio-Oss group increased significantly at 3 months after surgery compared to 1 month after surgery, but were significantly lower than the preoperative level and significantly lower than the PRF group (all P<0.05); . The levels of each index in the PRF group were significantly higher than those in the Bio-Oss group (all P<0.05); Pearson correlation analysis of BMD and the levels of growth factors PDGF, VEGF and TGF-β indexes showed positive correlation (all P<0.05). Conclusion: PRF implantation in patients undergoing extra-maxillary sinus lift surgery can promote the early formation of new bone in the extra-maxillary sinus and achieve good clinical results.

Key words： PRF Bio-Oss bone powder Extra-maxillary sinus elevation Bone mineral density Growth factor

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	Articles by authors
	DING Minghui
	KONG Lingbing
	YANG Jinyu
	et al

Cite this article:

DING Minghui,KONG Lingbing,YANG Jinyu, et al. A Comparative Study on the Application Value of PRF and Bio-Oss Bone Powder in Extra-Maxillary Sinus Lift Surgery[J]. HeBei Med, 2023, 29(6): 990-994.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2023.06.021 OR http://www.hbyxzzs.cn/EN/Y2023/V29/I6/990

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