HPV感染与ERK信号通路关键因子在宫颈癌中的交互效应及临床意义

doi:10.3969/j.issn.1006-6233.2023.06.015

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Abstract Objective: To investigate the interactive effects and significance of HPV infection and key factors of ERK signaling pathway in cervical cancer. Methods: Ninety patients with cervical cancer admitted to our hospital from October 2020 to October 2022 were selected as the study group, and another 90 patients with cervical intraepithelial neoplasia were included as the control group. The HPV infection status, ERK signaling pathway key factors [nuclear inhomogeneous ribonucleoprotein E1 (HnRNP E1), phosphorylated extracellular signal-regulated kinase 1/2 (p-ERK1/2), and phosphorylated non-receptor tyrosine kinase (p-Src)] expression were counted in both groups, and the expression of ERK signaling pathway key factors in patients with different clinicopathological characteristics in the study group was compared. The correlation between the two was analyzed with Spearman analysis and Logistic regression equation analysis was conducted to determine the interaction effect between HPV infection and key factors of the ERK signaling pathway in cervical cancer. Results: The HPV infection rate and the positive rates of HnRNP E1, p-ERK1/2 and p-Src protein in the study group were higher than those in the control group for CIN grade Ⅰ~Ⅱ and Ⅲ (P<0.05); the FIGO stage, HPV infection and differentiation degree of cervical cancer patients were positively correlated with HnRNP E1, p-ERK1/2 and p-Src protein (P<0.05); HnRNP E1, p-ERK1/2, p-Src protein and the interaction of the three were high-risk factors for HPV infection in cervical cancer patients (P<0.05). Conclusion: Both HPV infection and positive expression of key factors of ERK signaling pathway can increase the risk of cervical cancer, and there is a positive interaction between the two, which can provide favorable reference for the identification and treatment of cervical cancer.

Key words： Cervical cancer HPV infection ERK signaling pathway HnRNP E1 p-ERK1/2 P-Src

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	ZHANG Xiaomin
	YANG Nianhong

Cite this article:

ZHANG Xiaomin,YANG Nianhong. Interactive Effects of HPV Infection and Key Factors of the ERK Signaling Pathway in Cervical Cancer and Clinical Implications[J]. HeBei Med, 2023, 29(6): 957-962.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2023.06.015 OR http://www.hbyxzzs.cn/EN/Y2023/V29/I6/957

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