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Changes in Expression Levels of MAGE-As Protein and mRNA in Lung Cancer Patients and Their Clinical Significance |
LI Yanyong, ZHAO Xueqiang, CHEN Jiawen, et al |
The Second Affiliated Hospital of Guilin Medical College, Guangxi Guilin 541199, China |
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Abstract Objective: To investigate the expression and clinical significance of melanoma associated antigen (MAGE)-As protein and mRNA in non-small cell lung cancer. Methods: A total of 88 patients with non-small cell lung cancer treated in our hospital from January 2015 to January 2020 were selected, and the adjacent tissues were selected as the control, the expression of MAGE-As protein in lung cancer and adjacent tissues was detected by Western blot, and the expression of MAGE-As mRNA in lung cancer and adjacent tissues was detected by RT-PCR. Results: The relative expression levels of MAGE-As protein and mRNA in NSCLC tissues were (0.343 ± 0.101) and (0.728 ± 0.112), which were significantly higher than those in adjacent tissues (P<0.05); the relative expression of MAGE-As protein in stage Ⅲ ~Ⅳ lung cancer was (0.385 ± 0.102), which was significantly higher than that in stage Ⅰ~ Ⅱ lung cancer (P<0.05); there were no significant difference in the relative expression of MAGE-As protein in different gender, age, tumor diameter, pathological type and differentiation degree (P>0.05); the relative expression of MAGE-As mRNA in clinical stage Ⅲ~ Ⅳ and moderately and moderately differentiated lung cancer tissues were (0.762 ± 0.112) and (0.742 ± 0.107), which were significantly higher than those in stage Ⅰ~Ⅱ and well differentiated lung cancer tissues (P<0.05); there were no significant difference in the relative expression of MAGE-As mRNA in different gender, age, tumor diameter and pathological type (P>0.05). The median overall survival of patients with high and low MAGE-As mRNA expression in lung cancer tissues was 33 and 44 months, with a difference in survival between patients with high and low MAGE-As mRNA expression (P<0.05). The difference in median overall survival between patients with high and low MAGE-As protein expression was not statistically significant (P>0.05). Conclusion: The expression of MAGE as protein and mRNA are up-regulated in non-small cell lung cancer, is related to the severity of the disease, and the prognosis of patients with high expression of MAGE As mRNA is poor.
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