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| Association of VILIP-1 Annexin A2 and sEPCR with Outcomes of Acute Emergency Department Cerebral Infarction Patients after Intravenous Thrombolysis |
| WANG Gang, GONG Bo, YU Zhiguo, et al |
| The Central Theater Command General Hospital, Hubei Wuhan 430070, China |
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Abstract Objective: To investigate the relationship between visinin-like protein-1 (VILIP-1), Annexin A2, soluble vascular endothelial cell protein C receptor (sEPCR) and outcomes of patients with acute cerebral infarction (ACI) after intravenous thrombolysis. Methods: A total of 203 ACI patients treated in the emergency department of our hospital from January 2020 to January 2022 were retrospectively selected as the ACI group, and divided into good outcome group (n=158) and poor outcome group (n=45) according to the outcomes of patients after intravenous thrombolysis, and 100 healthy people who underwent physical examination in our hospital during the same period were selected as the healthy group. The levels of VILIP-1, Annexin A2, sEPCR were detected, and the relationship between VILIP-1, Annexin A2 and sEPCR and the condition of ACI patients was analyzed. The general data of the good outcome group and the poor outcome group, as well as the dynamic change trend of the levels of VILIP-1, Annexin A2 and sEPCR before, immediately after and 2h after intravenous thrombolysis were compared. The difference between VILIP-1, Annexin A2, and sEPCR before thrombolysis and 2h after thrombolysis (△VILIP-1, △Annexin A2, △sEPCR) was calculated to clarify the value of △VILIP-1, △Annexin A2, and △sEPCR in diagnosing the outcome of ACI patients. Results: VILIP-1[8.12±1.09 (μg/mL) vs 8.12±1.09 (μg/mL)] and sEPCR[145.63±20.93 (μg/L) vs 100.32±10.54 (μg/L)] in ACI group were higher than those in healthy group. Annexin A2[17.14±1.63 (ng/mL) vs 34.34±2.76 (ng/mL)] was lower than that in the healthy group (t=64.740, 20.400, 67.980, all P<0.05). As the condition of ACI patients worsened, VILIP-1 [6.54±0.78 (μg/mL) vs 10.98±1.44 (μg/mL) vs 13.42±1.56 (μg/mL)], sEPCR [119.98±20.93 (μg/L) vs 135.32±15.64 (μg/L) vs 156.82± 16.74 (μg/L)] were elevated and Annexin A2 [25.63±2.31 (ng/mL) vs 19.08±1.88 (ng/mL) vs 13.42±1.09 (ng/mL)] were decreased (F=45.517, 15.633, 53.977, all P<0.05). Conclusion: VILIP-1 and sEPCR decreased and Annexin A2 increased during intravenous thrombolytic therapy for acute cerebral infarction, which can dynamically monitor the changes of the above indicators to early diagnose and predict the outcomes of patients and improve the prognosis of patients.
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[1] Edwards MD,Hughes TAT.Managing blood pressure in acute cerebral infarction[J].Neurol, 2021,268(6):2294-2296.
[2] 庞旭阳.急性脑梗死患者血清salusin-α、VILIP-1水平变化及影响因素分析[J].国际检验医学杂志,2020,41(12):1435-1438,1444.
[3] Wang X,Fan X,Yu Z,et al.Effects of tissue plasminogen activator and annexin A2 combination therapy on long-term neurological outcomes of rat focal embolic stroke[J].Stroke, 2014,45(2):619-622.
[4] Faille D,Labreuche J,Meseguer E,et al.Endothelial markers are associated with thrombolysis resistance in acute stroke patients[J].Eur Neurol, 2014,21(4):643-647.
[5] 袁俊亮,张晓丹,李海英,等.smRSq量表在部分中国脑卒中人群中信度和效度的初步研究[J].临床神经病学杂志,2016,29(3):161-163.
[6] 包璐,邵祥忠,秦延昆,等.脑梗死患者血清VILIP-1、胱抑素C和SSA表达情况与其认知障碍的相关性及发生认知障碍的logistics分析[J].中国急救复苏与灾害医学杂志,2021,16(3):253-256.
[7] 郑守冰,林振中,叶小香.血清VILIP-1、尿酸、CRP、NSE水平与脑梗死患者预后的关系研究[J].检验医学与临床,2020,17(10):1332-1335.
[8] 贾文歆,王丽香,于振江.血清8-OHdG、VILIP-1水平对ACI患者静脉溶栓后发生HT的预测价值[J].山东医药,2022,62(19):70-73
[9] Weiss R,Bushi D,Mindel E,et al.Autoantibodies to Annexin A2 and cerebral thrombosis:Insights from a mouse model[J].Lupus, 2021,30(5):775-784.
[10] 徐燕,高阳.CTPI参数、sdLDL-C、Annexin A2、Hcy与急性脑梗死病情程度关联性及评估阿替普酶静脉效果价值[J].影像科学与光化学,2021,39(5):671-677.
[11] 钱骏,黄中伟,徐建如,等.sEPCR在脓毒症患者中的表达及临床意义[J].中国医药导报,2021,18(10):88-91.
[12] 周文来,田琳,李充沛,等.深静脉血栓形成患者外周血sEPCR、PAI-1水平与D-D水平的相关性及其诊断价值[J].血栓与止血学,2022,28(5):167-171.
[13] 王乐,杨增烨,王柳毅.急性脑梗死患者可溶性血管内皮细胞蛋白C受体和血管性血友病因子与白介素-6及病情严重程度的相关性探讨[J].国际神经病学神经外科学杂志,2021,48(2):126-129. |
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2023, Vol. 29 
