甲亢患者左心功能障碍发生与血清25羟维生素D BNP的关系

doi:10.3969/j.issn.1006-6233.2023.05.019

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Abstract Objective: To investigate the occurrence of left ventricular dysfunction in patients with hyperthyroidism and its relationship with serum levels of 25 hydroxyvitamin D [25 (OH) D], brain natriuretic peptide (BNP). Methods: 71 patients with hyperthyroidism combined with left ventricular dysfunction treated in our hospital from January 2021 to June 2022 (observation group) were selected, including 41 patients with left ventricular systolic dysfunction and 30 patients with left ventricular diastolic dysfunction. At the same time, 71 patients with simple hyperthyroidism (control group) were selected. The differences in clinical data of each group were compared, and the differences in echocardiographic parameters of patients with left ventricular systolic dysfunction and left ventricular diastolic dysfunction were analyzed. Results: The course of hyperthyroidism in the observation group was (21.32 ± 3.48) months, which was significantly higher than that in the control group (P<0.05). BNP in the observation group was (2.81± 0.72) ng/L, which was significantly higher than that in the control group (P<0.05), while 25 (OH) D was (15.12 ± 4.22) ng/ml, respectively, which were significantly lower than that in the control group (P<0.05). BNP of patients with left ventricular systolic dysfunction was (2.98 ± 0.60) ng/L, which was significantly higher than that of patients with diastolic dysfunction (P<0.05), while 25 (OH) D were (13.83 ± 3.11) ng/ml, which were significantly lower than those of patients with left ventricular diastolic dysfunction (P<0.05). 25 (OH) D was positively correlated with LVEF (r=0.665, P<0.05); BNP was negatively correlated with LVEF (r=-0.759, P<0.05), but positively correlated with E/A (r=0.787, P<0.05). The ROC area under the curve diagnosised by 25 (OH) D, BNP for left ventricular dysfunction were 0.837 and 0.951, respectively, P<0.05. Conclusion: In patients with hyperthyroidism and left ventricular dysfunction, the BNP level increase significantly, and 25 (OH) D decrease significantly, which has certain application value in diagnosis left ventricular dysfunction.

Key words： Hyperthyroidism Left ventricular dysfunction Serum 25 hydroxyvitamin D Brain natriuretic peptide

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2023.05.019 OR http://www.hbyxzzs.cn/EN/Y2023/V29/I5/794

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