甲氨蝶呤联合UACE在CSP患者妊娠物清除中应用研究

doi:10.3969/j.issn.1006-6233.2023.05.018

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Abstract Objective: To investigate the application effect of methotrexate combined with uterine arterial chemoembolization (UACE) in the removal of pregnancy substances in patients with cesarean scar pregnancy (CSP). Methods: A total of 84 CSP patients admitted to our hospital from May 2020 to December 2021 were selected and divided into an observation group and a control group according to the random number table method, with 42 cases in each. The control group was given methotrexate, and the observation group was given methotrexate combined with UACE. The data were compared including clinical efficacy, general operation, disappearance time of pregnancy substance, time to return to normal blood β-HCG, ovarian function indexes [follicle-stimulating hormone]. (FSH), luteinizing hormone (LH), estradiol (E2), progesterone (PROG)], and occurrence of complications. Results: The total effective rates of the observation group and the control group were 97.62% and 83.33%, respectively. The observation group had higher effective rate than the control group (P<0.05). The intraoperative blood loss in the observation group was significantly less than that in the control group, and the hospital stay was significantly shorter than that in the control group (P<0.05), while there was no significant difference in operation time between the two groups (P>0.05). The time to disappearance of pregnancy material and the time to normalization of blood β-HCG in the observation group were significantly earlier than those in the control group (P<0.05). There was no significant difference in the effect of different treatment methods on ovarian function indexes between the two groups at 3 and 6 months after operation (P>0.05). The incidence of complications in the observation group and the control group were 7.14% and 11.90%, respectively, and the difference was not statistically significant (P>0.05). Conclusion: Methotrexate combined with UACE has good curative effect on CSP patients, can effectively improve the symptoms of patients, reduce intraoperative blood loss and shorten the hospitalization time, and at the same time effectively remove pregnancy substance, and has less impact on ovarian function and fewer complications.

Key words： Methotrexate Uterine arterial chemoembolization Cesarean scar pregnancy Removal of pregnancy material

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	SHI Ping
	GENG JiaoJiao
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SHI Ping,GENG JiaoJiao,et al. Application of Methotrexate Combined with UACE in the Removal of Pregnancy Substances in CSP Patients[J]. HeBei Med, 2023, 29(5): 790-794.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2023.05.018 OR http://www.hbyxzzs.cn/EN/Y2023/V29/I5/790

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