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| Level of Serum 25-Hydroxyvitamin D and Its Correlation with IL-8 TNF-α and TLR2 in Patients with Different Severity of Acne |
| ZHANG Xiaofang, GAO Jun, JIANG Hui, et al |
| Yantai Affiliated Hospital of Binzhou Medical College, Shandong Yantai 264100, China |
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Abstract Objective: To explore the correlation between serum 25-hydroxyvitamin D and interleukin-8 (IL-8), tumor necrosis factor (TNF-α), Toll-like receptor 2 (TLR2) in patients with different severity of acne. Methods: A total of 218 patients with acne admitted to the hospital were enrolled as acne group between October 2019 and December 2021. All underwent serological tests. According to pillsbury grading, they were divided into grade I group, grade II group, grade III group and grade IV group. A total of 218 healthy controls during the same period were randomly enrolled as control group. The levels of serum IL-8, TNF-α, TLR2 and 25-hydroxyvitamin D were compared between acne group and control group, and among patients with different pillsbury grading. The correlation between serum 25-hydroxyvitamin D and IL-8, TNF-α, TLR2 was analyzed by Pearson correlation analysis. The correlation between pillsbury grading and serum IL-8, TNF-α, TLR2, 25-hydroxyvitamin D was analyzed by Spearman correlation analysis. Results: The levels of serum IL-8, TNF-α, TLR2 and 25-hydroxyvitamin D in acne group were significantly higher than those in control group (P<0.05). The levels of serum IL-8, TNF-α, TLR2 and 25-hydroxyvitamin were the highest in grade IV group, followed by grade III group, grade II group and grade I group (P<0.05). Pearson correlation analysis showed that level of serum 25-hydroxyvitamin D was positively correlated with levels of serum IL-8, TNF-α and TLR2 (P<0.05). Spearman correlation analysis showed that pillsbury grading was positively correlated with levels of serum IL-8, TNF-α, TLR2 and 25-hydroxyvitamin D (P<0.05). Conclusion: Serum 25-hydroxyvitamin D levels in acne patients are correlated with inflammatory factors and acne severity and can be used for clinical assessment of disease progression.
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2023, Vol. 29 
