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| Correlation of EGR1 Expression in Triple-Negative Breast Cancer Tissues with Clinicopathological Features and Prognosis |
| TANG Liangcheng, LV Dong, XU Fang |
| Chuzhou Hospital Affiliated to Anhui Medical University/Chuzhou First People's Hospital, Anhui Chuzhou 239000, China |
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Abstract Objective: To analyze the correlation of early growth response gene 1 (EGR1) expression and clinicopathological features and prognosis in triple negative breast cancer (TNBC). Methods: Fifty patients with TNBC and 53 patients with non-TNBC breast cancer treated in our hospital from January 2016 to March 2018 were enrolled for the research. The expression levels of EGR1 of TNBC cancer tissue, non-TNBC cancer tissue and adjacent normal tissue were compared, and the correlation between EGR1 expression in TNBC cancer tissue and clinicopathological features and prognosis was analyzed. Results: The incidence of EGR1 high expression of TNBC cancer tissue was significantly lower than that of non-TNBC cancer tissue and adjacent normal tissue, and the incidence of EGR1 high expression of non-TNBC cancer tissue was significantly lower than that of adjacent normal tissue (P<0.05). The incidence of EGR1 high expression in cancer tissue of TNBC patients with tumor diameter ≥ 3cm, histological grade G3, metastasis of lymph node, TNM stage Ⅲ and Ki-67 index ≥ 50% was significantly lower than those patients with tumor diameter < 3cm, G2 and G1, without metastasis of lymph node, stage I and < 50%, and the incidence of EGR1 high expression of TNBC cancer tissue with G2 and stage II was significantly lower than those with G1 and stage I (P<0.05). The median survival time of TNBC patients with high EGR1 expression was significantly lower than those with low EGR1 expression (P<0.05).Results: of multivariate Cox regression analysis showed that lymph node metastasis was an independent risk factor for poor prognosis of TNBC patients, and the high expression of EGR1 in cancer tissue was an independent protective factor of poor prognosis (P<0.05). Conclusion: The expression of EGR1 in TNBC cancer tissue was low, and the high expression of EGR1 in cancer tissue was an independent protective factor for the death of patients.
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2023, Vol. 29 
