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| Short-Term Efficacy of Choledochojejunostomy plus T-tube Drainage in the Treatment of Gallbladder Cancer and Its Effects on Median Survival Time and Postoperative Complications |
| ZHAO Li, LI Yun, SHU Yijun, et al |
| Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200092, China |
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Abstract Objective: To explore the short-term efficacy of cholecystectomy plus bile duct T-tube drainage or choledochojejunostomy (CJ) in the treatment of gallbladder cancer (GC) and its effects on the median survival time and postoperative complications. Methods: The clinical data of 121 patients who underwent laparoscopic cholecystectomy (LC) in department of hepatobiliary surgery of the hospital from January 2018 to December 2018 were retrospectively analyzed. According to the adjuvant treatment methods, the patients were divided into two groups: including control group (n=61, LC+bile duct T-tube drainage) and observation group (n=60, LC+CJ). The perioperative indicators, immune stress response, postoperative complications, short-term efficacy, and median survival time were compared between the two groups of patients. Results: The surgical time, postoperative anal first exhaust time, and intraoperative blood loss in observation group were no different from those in control group (P<0.05), but the hospital stay was shorter than that in control group (P<0.05). The changes of immunoglobulin M (IgM), immunoglobulin G (IgG) and C-reactive protein (CRP) before and after surgery in observation group were lower than those in control group (P<0.05). The total incidence rate of complications in observation group at 14 days after surgery was lower than that in control group (P<0.05). There was no statistical significance in the effective rate of treatment between observation group and control group (P>0.05). There was no statistical difference between the two groups in terms of survival rate (P>0.05). Conclusion: Compared with bile duct T-tube drainage, GC+CJ in the treatment of GC can better shorten the postoperative hospital stay and reduce the postoperative complications and immune stress response, but and the median survival time of the two is similar, which can be promoted in clinical practice.
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2023, Vol. 29 
