|
|
|
| Eexpression and Clinical Significance of sTREM-1 and PTX3 in Pleural Effusion of Tuberculous Pleurisy |
| LI Jianrong, ZHANG Tingting, HUANG Liyun, et al |
| The Second People's Hospital/The Second Hospital of Three Gorges University, Hubei Yichang 443000, China |
|
|
|
|
Abstract Objective: To explore the expression levels of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) and pentraxin 3 (PTX3) in the pleural effusion of patients with tuberculous pleurisy(TBP), and analyze their clinical significance. Methods: Ninety-eight patients with TBP (TBP group) admitted in our hospital and 84 non-TBP patients whose general data matched with the TBP group during the same period were selected as the non-TBP group. The patients in the TBP group were divided into a good prognosis group (70 cases) and a poor prognosis group (28 cases) according to the treatment effect. Enzyme-linked immunosorbent assay was used to detect the expression levels of sTREM-1 and PTX3 in pleural effusion, and the differences in sTREM-1 and PTX3 were analyzed between TBP group and non-TBP group, between good prognosis group and poor prognosis group; ROC curve was used to analyze the effects of sTREM-1 and PTX3 expression in pleural effusion on the early diagnosis and prognosis of TBP. Results: The expression levels of sTREM-1 and PTX3 in pleural effusion in TBP group were significantly higher than those in non-TBP group (t=13.516, 12.036, P<0.05); ROC analysis showed that the area under the curve of sTREM-1 combined with PTX3 in diagnosing TBP was 0.962, which was larger than 0.925 and 0.870 for sTREM-1 and PTX3 alone (Z=2.910, 4.233, P<0.05); the expression levels of sTREM-1 and PTX3 in the poor prognosis group were higher than those in the good prognosis group (t=10.051, 11.729, P<0.05); the area under the curve of sTREM-1 combined with PTX3 was 0.971, which was larger than 0.894 and 0.911 for sTREM-1 and PTX3 alone (Z=1.969, 2.356, P<0.05). Conclusion: The expression levels of sTREM-1 and PTX3 in the pleural effusion of patients with TBP increased. The expression levels of sTREM-1 and PTX3 in the pleural effusion of patients with poor prognosis were higher than those of patients with good prognosis. sTREM-1 combined with PTX3 could be used to identify the occurrence of TBP and to diagnose the prognostic effect.
|
|
|
|
|
|
[1] Wu H,Wei J,Yu D.Application of NGS in diagnosis of tuberculous pleurisy with multiple negative tests:a case report[J].Infect Drug Resist,2020,13(1):3543-3550.
[2] Lei X,Wang J,Yang Z.Diagnostic accuracy of pleural effusion mononuclear cells/leukocyte ratio in tuberculous pleurisy[J].Front Med (Lausanne),2021,8(1):1-7.
[3] Han Q,Deng H,Fan X,et al.Increased serum pentraxin 3 levels are associated with poor prognosis of hepatitis B virus-related hepatocellular carcinoma[J].Hepatocell Carcinoma,2021,8(1):1367-1373.
[4] 中华医学会结核病学分会.《肺结核诊断和治疗指南》[J].中国实用乡村医生杂志,2013,20(2):70-74.
[5] Fenhua J,Daohui W,Hui L,et al.Diagnostic value of combined pleural interleukin-33,adenosine deaminase and peripheral blood tuberculosis T cell spot detection TB for tuberculous pleurisy[J].BMC Infect Dis,2021,21(1):1-8.
[6] 彭泽,黄健,任莉,等.胸腔积液IGRA、ADA、IL-27诊断结核性胸膜炎患者的价值[J].热带医学杂志,2021,21(9):1175-1179.
[7] 黄文辉,何轶群,李娟,等.sTREM-1、Presepsin对儿童脓毒症诊断和预后评估的价值[J].中国现代医学杂志,2021,31(19):7-13.
[8] 陈加贝,方松,李斌,等.脑脊液strem-1水平在神经外科术后细菌性脑膜炎早期临床诊断中的意义[J].中华神经医学杂志,2021,20(10):1027-1031.
[9] 陈红梅,余艳艳,方喆,等.中性粒细胞白细胞分化抗原64指数联合可溶性髓样细胞触发受体1对肺结核合并肺部细菌感染患者的诊断价值[J].中国医药,2021,16(10):1539-1542.
[10] Asgari F,Supino D,Parente R,et al.The long pentraxin PTX3 controls klebsiella pneumoniae severe infection[J].Front Immunol,2021,12(1):1-12.
[11] 高军,葛宇君,张军.胸部创伤患者早期血清PTX3和α-MSH及CRP水平与创伤后细菌感染的相关性分析[J].中国微生态学杂志,2021,33(6):674-678. |
|
|
|
2023, Vol. 29 
