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| Clinical Study on Postoperative Pain of Mixed Hemorrhoids with Methylene Blue Blocking Injection Combined with Ketochromic Acid Tromethamine |
| GAO Yingjie, BI Wenjing, HAN Guochao, et al |
| The Affiliated Hospital of Chengde Medical University, Hebei Chengde 067000, China |
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Abstract Objective: To investigate the efficacy of methylene blue blocking injection combined with keto chromic acid tromethamine in the treatment of postoperative pain of mixed hemorrhoids. Methods: A total of 80 cases of mixed hemorrhoids admitted from January 2020 to December 2021 were divided into an experimental group and a control group, with 40 cases in each group. As to the experimental group, after the operation, methylene blue long-acting analgesic (1% methylene blue 2mL+water for injection 5mL+0.375% ropivacaine 5mL)+ketochromic tromethamine 60mg intramuscular injection was injected into the wound sealing. As to the control group, keto chromic acid tromethamine 30~60mg intramuscular injection was used as required, with the daily dose<120mg. Results: The pain scores at 6h, 1d, 3d, and 7d after the operation were statistically different (P<0.001, P<0.05), and the pain scores at 14d after the operation were not statistically different (P=0.602, P>0.05), namely, the pain of the patients in the experimental group in the first two weeks was significantly less than that of the patients in the control group, and the incision pain of the patients in the two groups was not significantly different after two weeks. In the comparison between the two groups of patients under strong stimulation (defecation and dressing change), there was a statistical difference in pain scores P<0.001 (P<0.05), namely, the pain of patients in the experimental group during defecation and dressing change was significantly less than that of patients in the control group. Conclusion: Methylene blue blocking injection combined with keto chromic acid tromethamine can significantly reduce postoperative pain, improve postoperative quality of life, and reduce postoperative urinary retention. This scheme is a safe and effective treatment measure, which is worthy of clinical application.
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2023, Vol. 29 
