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| Effects of Bio-Oss Bone Meal Combined with PRF and GBR Technology on Peri-Implant Bone Regeneration and Peri-Implantitis |
| HUANG Xuchen, et al |
| Beijing Chaoyang Hospital,Capital Medical University, Beijing 100000, China |
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Abstract Objective: To explore the effect of Bio-Oss bone meal combined with PRF and GBR technology on peri-implant bone regeneration and peri-implantitis. Methods: A total of 90 patients who underwent oral implant-guided bone regeneration in our hospital from February 2020 to April 2022 were selected as the research subjects, and divided into 3 groups according to the order of admission. Thirty cases in the Bio-Oss group were given Bio-Oss bone meal combined with guided bone regeneration (GBR) for guided regeneration, 30 cases in the PRF group were given platelet-rich fibrin (PRF) combined with GBR technique for guided regeneration, and 30 cases in the combined group were given Bio-Oss bone meal Combined PRF and GBR technology to guide regeneration. The peri-implant bone regeneration at 1 month and 3 months after operation among the three groups, pain at 24 hours after the operation, mucosal swelling at the surgical site at 1 week after the operation, and the plaque index (PLI) before surgery, 1 month, and 3 months after surgery probing depth (PD), and postoperative complications were compared among the three groups. Results: At 1 month and 3 months after the operation, the height of the bone graft and the thickness of bone formation in the combined group were significantly higher than those in the Bio-Oss group and the PRF group (P<0.05). There was no significant difference in the bone graft height and bone formation thickness between the Bio-Oss group and the PRF group (P>0.05); 24 hours after the operation, the pain in the combined group was significantly better than that in the other two groups (P<0.05), while there was no significant difference between the other two groups (P>0.05). One week after the operation, the mucosal swelling in the combined group was significantly lighter than that in the Bio-Oss group and the PRF group (P<0.05), while there was no significant difference between the Bio-Oss and PRF groups (P>0.05). At 1 month and 3 months after the operation, the PLI and PD of the three groups were significantly lower than those before the operation (P<0.05). And the PLI score and PD of the combined group were significantly lower than those of the Bio-Oss group and the PRF group(P<0.05). However, there was no significant difference between the PRF group and the Bio-Oss group (P>0.05). There was no significant difference in the total incidence of postoperative complications among the three groups (P>0.05). Conclusion: The application of Bio-Oss bone powder combined with PRF and GBR technology in oral implant-guided bone regeneration can help promote postoperative bone defect regeneration, reduce postoperative pain, promote soft tissue regeneration, reduce mucosal swelling, and promote obvious peri-implant soft tissue inflammation improved, and the safety is high, which is worthy of clinical application.
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[1] 严戈辉,薛瑞,郭发健,等.可吸收与不可吸收口腔修复膜在牙种植中引导骨再生临床疗效的Meta分析[J].中国循证医学杂志,2019,19(5):578-586.
[2] 桑文涛,余芳蓉,杨泽越,等.康复新液防治口腔疾病的研究进展[J].世界中医药,2019,14(1):251-256.
[3] 杨瑞,张思佳,宋爽,等.引导骨再生对下颌后牙种植体边缘骨吸收影响的十年回顾性队列研究[J].中华口腔医学杂志,2021,56(12):1211-1216.
[4] 曹钰彬,刘畅,潘韦霖,等.引导骨再生屏障膜改良的研究进展[J].华西口腔医学杂志,2019,37(3):325-329.
[5] 赵伟,廖农,王君,等.自体脂肪颗粒分别联合自体富血小板血浆和富血小板纤维蛋白修复面部凹陷畸形的疗效比较[J].临床皮肤科杂志,2021,50(4):236-240.
[6] 路佳佳,李伟琼,许敏,等.BoneCeramic和Bio-Oss骨粉对狗骨髓间充质干细胞体外成骨分化能力影响的比较研究[J].中国药理学通报,2021,37(4):511-516.
[7] 黄稍稍,谭荣才,邝晓岚.Bio-Oss骨粉联合富血小板纤维蛋白在牙槽骨缺损种植引导骨再生后的骨量变化[J].上海口腔医学,2020,29(4):427-430.
[8] 闫娜,黄涛,张中月,等.富血小板纤维蛋白联合GBR技术在种植体周围炎骨缺损重建的临床应用[J].实用医学杂志,2020,36(6):813-817.
[9] 董瑶,董飞君,潘凌峰.Bio-Oss骨粉联合富血小板纤维蛋白对口腔种植引导性骨再生术后黏膜愈合和骨缺损再生的影响研究[J].中国全科医学,2017,20(S3):152-154.
[10] 高秀秋,程焕芝,孙良玉.Bio-Oss骨粉混合PRF修复牙周骨缺损的临床观察[J].医学与哲学(B),2015,36(5):32-33.
[11] 郑冬冬,付欣,魏娜,等.CGF双膜覆盖应用于上颌前牙区骨缺损引导骨再生术的成骨能力及口腔组织再生效果研究[J].临床和实验医学杂志,2022,21(7):748-752. |
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2023, Vol. 29 
