七叶皂苷钠联合骨肽注射液对老年跟骨骨折术后肢体肿胀的疗效及血清BALP BGP的影响

doi:10.3969/j.issn.1006-6233.2023.02.011

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Abstract Objective: To investigate the effect of sodium aescinate combined with bone peptide injection on limb swelling after calcaneal fracture surgery in elderly patients and the influence of serum bone alkaline phosphatase (BALP) and Osteocalcin (BGP). Methods: A total of 102 elderly patients with limb swelling after calcaneal fracture treated in our hospital from April 2018 to October 2020 were selected and divided into 2 groups using random number table method. The control group received sodium aescinate 10mg,qd; the treatment group was treated with sodium aescinate 10mg, qd combined with bone peptide injection 10ml, qd, and the 2 groups were treated for 2 weeks. The leg circumference difference, limb swelling score, visual analogue scale (VAS) score, serum BALP and BGP levels were recorded, and the clinical efficacy was compared between the two groups. Results: Compared with the clinical effective rate of 86.27% in the control group, the effective rate of the experimental group was 96.08% (P<0.05). Compared with before treatment, the difference of calf circumference, swelling score and VAS score in the two groups were decreased after treatment. Compared with the control group, the difference of calf circumference difference, swelling score and VAS score before and after treatment in the experimental group were higher, and the differences were statistically significant (P<0.05). Compared with before treatment, serum BALP and BGP levels increased after treatment (P <0.05). Compared with the control group, the differences in serum BALP and BGP levels before and after treatment in the experimental group were higher, and the differences were statistically significant (P<0.05). Conclusion: Sodium aescinate combined with bone peptide injection has definite curative effect on limb swelling after calcaneal fracture surgery in the elderly, can improve bone metabolism, and has high safety, which is worthy of promotion.

Key words： Sodium aescinate Osteopeptide injection Senile calcaneal fracture Postoperative limb swelling BALP BGP

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2023.02.011 OR http://www.hbyxzzs.cn/EN/Y2023/V29/I2/236

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