输注不同治疗剂量血小板对急性淋巴细胞白血病患儿血清铁蛋白水平及短期预后的影响分析

doi:10.3969/j.issn.1006-6233.2022.12.018

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Abstract Objective: To compare the effects of different doses of platelet transfusion on serum ferritin level and short-term prognosis in children with acute lymphocytic leukemia (ALL). Methods: 109 children with ALL who received platelet transfusion from March 2019 to March 2021 in our hospital were selected. According to the actual platelet transfusion dose per unit body surface area of the children, the transfusion doses of < 2. 2×1011/m², 2. 2~4. 4×1011/m² and > 4. 4× 1011/m² were respectively included in the low dose group (n=37). The effects of platelet transfusion, 24-hour platelet count increase index (CCI), 24-hour platelet recovery rate (PPR) and serum ferritin levels before and after platelet transfusion were compared among the three groups, and the 1 year survival of the three groups was compared. Results: The platelet /BSA and PPI of low dose group were lower than those of middle dose group, and the platelet /BSA and PPI of middle dose group were lower than those of high dose group (P<0. 05). There was no significant difference in CCI and infusion efficiency among the three groups (P>0. 05). There were no obvious adverse events in the three groups during platelet transfusion. 24 hours after infusion, the platelet counts of both groups were higher than those before infusion, and the serum ferritin levels were lower than those before infusion. The difference of platelet counts before and after infusion in the middle dose group was higher than that in the low dose group, and the difference of platelet counts before and after infusion in the high dose group was higher than that in the high dose group, with statistical significance (P<0. 05). There was no significant difference in the event-free survival rate among the three groups after treatment (P>0. 05). Conclusion: Different therapeutic doses of platelet transfusion have no significant difference on serum ferritin level and short-term prognosis of children with ALL. Middle and high dose platelet transfusion can't improve CCI, so low dose platelet transfusion can be considered in clinical practice.

Key words： Platelet Acute lymphocytic leukemia Ferritin Prognosis

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	HUANG Bin
	DENG Zhihua
	WU Junjun
	et al

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HUANG Bin,DENG Zhihua,WU Junjun, et al. Effect of Different Therapeutic Doses of Platelet Transfusion on Serum Ferritin Level and Short-Term Prognosis in Children with Acute Lymphoblastic Leukemia[J]. HeBei Med, 2022, 28(12): 2034-2037.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2022.12.018 OR http://www.hbyxzzs.cn/EN/Y2022/V28/I12/2034

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