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| Transnasal Intermittent Positive Pressure Ventilation Combined with Pulmonary Surfactant in the Treatment of Respiratory Distress Syndrome in Low Weight Neonates |
| LI Ye, GAO Zhibo , LIU Yushen, et al |
| The Second Affiliated Hospital of Air Force Military Medical University, Shaanxi Xi'an 710038, China |
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Abstract Objective: To analyze the influence of transnasal intermittent positive pressure ventilation with pulmonary surfactant on low weight neonates with respiratory distress syndrome. Methods: The clinical data of 116 low weight neonates with respiratory distress syndrome who were delivered in obstetrics department of our hospital from November 2019 to October 2021 were retrospectively analyzed. They were divided into two groups, the observation group and the control group according to different treatment methods. The neonates in the control group were treated with routine transnasal intermittent positive pressure ventilation, while the neonates in the observation group were given pulmonary surfactant combined with transnasal intermittent positive pressure ventilation. The blood gas analysis, treatment effect, ventilator assisted treatment time, hospital stay and other related conditions and the incidence of ramification were compared between the two groups before and after treatment. Results: After treatment with different methods, the pH value, PaO2 and blood oxygen saturation of the two groups were significantly higher than those before treatment, while PaCO2 was significantly lower than those before treatment, and the differences were statistically significant (P<0. 05). The difference of pH value, PaO2, PaCO2 and blood oxygen saturation before and after treatment in the observation group was significantly greater than that in the control group (P<0. 05). The total effective rate of neonatal respiratory distress syndrome in the observation group was significantly higher than that in the control group (P<0. 05). The time of ventilator-assisted treatment, hospitalization and invasive mechanical ventilation in the observation group were shorter than those in the control group (P<0. 05). The total incidence of related complications in the observation group was lower than that in the control group (P<0. 05). Conclusion: Pulmonary surfactant combined with transnasal intermittent positive pressure ventilation is effective for low weight neonates with respiratory distress syndrome, and the time of ventilator assisted treatment and hospitalization is short, and the incidence of treatment-related complications is low, which is worthy of clinical application.
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2022, Vol. 28 
