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| Study on the Effects of Different Doses of Levothyroxine Dodium Tablet Treatment on Thyroid Hormones,Pregnancy Outcome and Offspring Psychological Developmental Functions in Pregnant Women with Hypothyroidism During Pregnancy |
| SHI Youwen, GAN Yu, XIE Qianqian, et al |
| No.901 Hospital,Joint Logistics Support Force of the Chinese People's Liberation Army, Anhui Hefei 230031, China |
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Abstract Objective: To study the effects of different doses of levothyroxine sodium tablets on thyroid hormones,pregnancy outcomes and offspring psychological development of women with hypothyroidism during pregnancy. Methods: A total of 100 pregnant women with hypothyroidism treated with levothyroxine sodium tablets in the hospital from August 2020 to August 2021 were selected.They were divided into group A (25ug/time,54 cases),group B (50ug/time,25 cases) and group C (75ug/time,21 cases) according to the dose.Relevant parameters in the three groups were comparatively analyzed. Results: Thyroid function indicators in the three groups showed no statistically significant difference before treatment (P>0.05).After treatment,the levels of thyroid stimulating hormone (TSH) and thyroid peroxidase antibody (TPO-Ab) were significantly decreased,and the levels of free triiodothyronine (FT3) and free thyroxine (FT4) were significantly increased in all groups.The increases or decreases were significantly greater in group C than in group A and group B (P<0.05).The glucose and lipid metabolism in the three groups showed no statistically significant difference before treatment (P>0.05).After treatment,fasting plasma glucose (FPG),fasting insulin (FINS),total cholesterol (TC),low-density lipoprotein cholesterol (HDL-C),and triglyceride (TG) were decreased,while high-density lipoprotein Cholesterol (HDL-C) was increased in the three groups.The changes in group C were greater than those in group A and group B (P<0.05).There were significant differences in the incidence rates of gestational diabetes mellitus and premature rupture of membranes among the 3 groups (P<0.05).The incidence of gestational diabetes mellitus in group C was significantly lower than that in group A (P<0.05).The other pregnancy outcomes of the 3 groups showed no statistically significant difference (P>0.05).The scores of offspring's gross motor,adaptability and social behavior in group C were significantly higher than those in group A and group B (P<0.05),but there was no statistically significant difference in language and fine motor (P>0.05). Conclusion: Compared with low-dose levothyroxine sodium tablets,high-dose levothyroxine sodium tablets can better maintain normal thyroid function in pregnant women with hypothyroidism,regulate their glucose and lipid metabolism,lower the risk of adverse pregnancy outcomes,and improve offspring's neuropsychological development.
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2022, Vol. 28 
