超声LCA/AoA RCA/AoA值在川崎病不同时期的变化及对预后的预测价值分析

doi:10.3969/j.issn.1006-6233.2022.10.026

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Abstract Objective: To detect the left common coronary artery (LCA) and right common coronary artery (RCA) internal diameters and aortic annulus (AoA) internal diameters in children with Kawasaki disease (KD) using ultrasound,calculate LCA/AoA and RCA/AoA values,and analyse the changes in their self-limiting recovery and their predictive value for prognosis in children with KD. Methods: A total of 126 KD children who were treated in our hospital from January 2020 to December 2021 were selected as the observation group,and 63 healthy children who underwent physical examination during the same period were selected as the control group.The LCA/AoA and RCA/AoA values of the observation group in the acute phase,subacute phase and recovery phase were compared with those in the control group.The incidence of coronary artery lesion (CAL) in the acute phase and 3 months after the onset of the observation group was counted.The influencing factors of prognosis of children were analyzed,and the value of LCA/AoA and RCA/AoA values in predicting prognosis was evaluated. Results: The LCA/AoA and RCA/AoA values of the observation group in the acute stage,subacute stage and recovery stage were higher than those in the control group (P<0.05).The LCA/AoA and RCA/AoA values in the subacute phase of the observation group were higher than those in the acute phase,but were lower in the recovery phase than those in the acute and subacute phases (P<0.05).The incidence of CAL in the observation group was lower than that in the acute stage after 3 months of onset (P<0.05).After correction of platelet count and C-reactive protein level,LCA/AoA and RCA/AoA values in the recovery period were the prognostic factors for children with KD (P<0.05).The AUC value of LCA/AoA for predicting left coronary artery disease during the recovery period was 0.902,and the AUC value for RCA/AoA for predicting right coronary artery disease was 0.850. Conclusion: Ultrasound LCA/AoA and RCA/AoA values change significantly during the self-limited recovery of KD,especially in the recovery period,LCA/AoA and RCA/AoA values can effectively predict the prognosis of children and they provide a reference for the adjustment of clinical treatment plans.

Key words： Ultrasound LCA/AoA RCA/AoA value Kawasaki disease Self-limited recovery Prognosis

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2022.10.026 OR http://www.hbyxzzs.cn/EN/Y2022/V28/I10/1719

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