甲钴胺对结直肠癌患者XELOX方案引起的外周神经病变的预防作用研究

doi:10.3969/j.issn.1006-6233.2022.10.023

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Abstract Objective: To study the preventive effect of mecobalamin on peripheral neuropathy (CIPN) induced by oxaliplatin + capecitabine (XELOX) regimen in patients with colorectal cancer. Methods: A total of 76 patients with colorectal cancer who were admitted to the Fourth Affiliated Hospital of Guangzhou Medical University from January 2020 to January 2022 were selected and divided into observation group and control group according to the random number table method,with 38 cases in each group.The control group was treated with XELOX regimen,and the observation group was treated with Mecobalamin Combined with XELOX regimen.After six chemotherapy cycles,the incidence of CIPN,nerve conduction velocity,level of inflammatory factors and incidence of adverse reactions were evaluated and compared among the groups. Results: The incidence of CIPN of grade II,III and IV in the observation group was lower than that in the control group (P<0.05).After treatment,the SNCV,MNCV of the median nerve and sural nerve in the observation group were higher than those in the control group (P<0.05).The levels of Nod-like receptor protein 3 (NLRP3),hypoxia-inducible factor-1α (HIF-1α) and B cell activating factor receptor (BAFF-R) in the observation group were lower than those in the control group (P<0.05).The scores of European Organization for Research and Treatment of Cancer Quality of Life Questionnaire(EORTC QLQ-C30) in the observation group were higher than those in the control group (P<0.05).During the treatment,the incidence of adverse reactions was 15.79% (6/38) in the observation group and 10.53% (4/38) in the control group,with no significant difference (P>0.05). Conclusion: Mecobalamin has a significant preventive effect on CIPN of XELOX regimen in patients with colorectal cancer.It can reduce the incidence of CIPN,and it can improve peripheral nerve conduction velocity,and it can inhibit the level of related inflammatory factors,and it can improve the quality of life of patients,and it has high clinical value.

Key words： Colorectal cancer Oxaliplatin Capecitabine Peripheral neuropathy Mecobalamin

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2022.10.023 OR http://www.hbyxzzs.cn/EN/Y2022/V28/I10/1701

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