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| Correlation of MRI Parameters with Epidermal Growth Factor Receptor 2 and Proliferating Cell Nuclear Antigen in Breast Cancer |
| WU Liping, ZHANG Nan, LIU Wenxia |
| Zaozhuang Maternal and Child Health Hospital, Shandong Zaozhuang 277000, China |
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Abstract Objective: To explore the correlation between T2WI signal characteristics and apparent diffusion coefficient (ADC) of MRI and cerbB-2 and Ki-67 expression in breast cancer patients. Methods: One hundred and seventeen breast cancer patients admitted to our hospital from June 2017 to April 2021 were selected.All patients underwent routine MRI imaging and immunohistochemical staining of specimens,and the correlation between T2WI signal characteristics and ADC values obtained from MRI imaging and immunohistochemical detection of cerbB-2 and Ki-67 positivity was recorded and analyzed. Results: The ADC values were (0.81±0.11) and (0.90±0.15) for positive and negative expression of cerbB-2,respectively,and the T2WI signal and ADC values were significantly higher for positive expression of cerbB-2 (P<0.05).T2WI high signal and ADC values were significantly lower (P<0.05).T2WI high signal and ADC values were factors influencing cerbB-2 positivity,and both were positively correlated with it (r=0.372,r=0.310,P<0.001,P=0.001); T2WI high signal and ADC values were factors influencing Ki-67 positivity,T2WI signal was positively correlated with Ki-67 positively and ADC values were negatively correlated with them (r=0.274,r=-0.476,P=0.003,P<0.001). Conclusion: In this paper,we leave aside the commonly used ultrasound and mammography examinations for breast cancer and use MRI as the main breakthrough point to investigate the relationship between T2WI signals,ADC values and body biologic factors.Most studies have focused on the ADC values and the results of MRI examinations,ignoring the role of T2WI signals in assessing the relationship between breast cancer and body biologic factors.In this paper,the combination of ADC values,T2WI signals and biologic factors is used to support the search for new targets for breast cancer treatment.The T2WI signal and ADC value are associated with the expression of cerbB-2 and Ki-67,which can be used as a reference for subsequent breast cancer treatment.
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2022, Vol. 28 
