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| Screening of Quantitative Parameters of CEUS and SWE in Diagnosing Peripheral Neuropathy in Type 2 Diabetes Mellitus Based on Logistic Regression Model |
| JIN lijia, et al |
| West China Hospital of Sichuan University, Sichuan Chengdu 610041, China |
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Abstract Objective: To screen the quantitative parameters of ontrast-enhanced ultrasound (CEUS) and shear wave elastography (SWE) in diagnosing peripheral neuropathy (PN) in type 2 diabetes mellitus (T2DM) based on Logistic regression model. Methods: Fifty patients with T2DM complicated with PN treated in our hospital from January 2019 to June 2021 were selected as PN group, 50 patients with T2DM without PN were selected as non-PN group, and 50 healthy adults were selected as control group. The conventional two-dimensional ultrasound examination [transverse diameter, anterior posterior diameter and cross-sectional area], SWE examination [elastic maximum value (Emax), elastic minimum value (Emin) and elastic mean value (Emean)], and CEUS examination [time to peak (TTP), intensity maximum value (Imax) and area under curve (AUC)] were compared among the three groups. Multivariate logistic regression analysis was performed to screen the ultrasonic examination parameters related to PN. Results: The transverse diameter, anterior posterior diameter, cross-sectional area, Emax, Emin, Emean and TTP of PN group were significantly higher than those in non-PN group and control group, the Imax and AUC of PN group were significantly lower than those in non-PN group and control group, the transverse diameter, anterior posterior diameter, cross-sectional area, Emax, Emin, Emean and TTP of non-PN group were significantly higher than those of control group, and the Imax and AUC of non-PN group were significantly lower than those of control group (P<0.017). Multivariate logistic regression analysis showed that Emean, TTP and Imax were the independent related factors of PN (P<0.05). Conclusion: CEUS parameters (including TTP, IMAX) and SWE parameters (mainly Emean) of tibial nerve have important diagnostic value for PN in T2DM patients, which is worthy of clinical application.
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2022, Vol. 28 
