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| Identification of Relationship between Helicobacter Pylori Infection and Serum SERPIN E1 Protein Level in Adults |
| YAO Yong, FENG Lei, LEI Hongjun, et al |
| Suining City Center Hospital, Sichuan Suining 629000, China |
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Abstract Objective: To identify the relationship between Helicobacter pylori (Hp)infection and serum SERPIN E1 protein level in adults and offer a theoretical basis for investigating the mechanisms by which Hp induces gastric cancer. Methods: A total of 417 subjects were allocated to the Hp-negative group(n=192) or the Hp-positive group(n=225). All participants had fully detailed records of biochemical data and results of serum SERPIN E1 testing. Results: Serum SERPIN E1 level was significantly different (P<0.01) between the Hp-negative group and Hp-positive group: 5.38(4.56~6.18)(ng/ml))versus 8.20(6.91~9.34) (ng/ml). All the participants were divided into 4 groups by quartile values of serum SERPIN E1 and a linear correlation between the prevalence of Hp infection and quartiles of serum SERPIN E1 levels was observed(P<0.001). Based on the receiver operating characteristic curve (ROC) for predicting Hp infection in participants, the serum level of SERPIN E1 with optimal sensitivity (84.4%) and specificity (83.3%) was about 6.49ng/ml and the area under the ROC curve was 0.906. Conclusion: Serum level of SERPINE1 is closely associated with Hp infection in adults. SERPIN E1 may play an important role in the pathogenesis of Hp-induced gastric cancer.
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2022, Vol. 28 
