RA伴肺间质病变患者血清KL-6水平及与T淋巴细胞亚群的关系

doi:10.3969/j.issn.1006-6233.2022.07.013

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Abstract Objective: To investigate the serum salivary liquefied carbohydrate antigen-6 (KL-6) level and its relationship with T lymphocyte subsets in patients with rheumatoid arthritis (RA) with interstitial lung disease (ILD). Methods: Seventy-five patients with RA with ILD in our hospital from September 2020 to September 2021 were selected as the study group,and 75 patients with RA alone in the same period were selected as the control group according to the 1:1 matching case-control principle.The general data of the two groups were compared,the serum KL-6 level was detected by enzyme-linked immunosorbent assay,the T lymphocyte subsets (CD3⁺,CD4⁺,CD8⁺) were detected by flow cytometry,and RA activity was assessed using the Disease activity score 28 (DSA 28),and the patients with different degrees of pulmonary ventilation disturbance and pulmonary diffusion dysfunction in the study group were compared.Serum KL-6 level,and the correlation between serum KL-6 level and T lymphocyte subsets,RA activity,degree of pulmonary ventilation disturbance,and degree of pulmonary diffusion dysfunction in the study group were analyzed.All patients in the study group received symptomatic treatment,and the curative effect was evaluated after 6 months of treatment.The serum KL-6 levels before treatment,1 month,3 months,and 6 months of treatment in patients with different curative effects were compared,and the value of serum KL-6 in predicting curative effect was evaluated by receiver operating characteristic (ROC) curve. Results: The serum KL-6 level and DSA 28 score of the study group were higher than those of the control group (819.65±85.34 vs 418.93±52.67,t=34.605,P<0.001;3.46±0.85 vs 2.59±0.77,t=6.569,P<0.001),and the levels of CD3⁺,CD4⁺ and CD8⁺ were lower than those of the control group (41.69±5.39 vs 44.86±5.72,t=3.493,P =0.001;17.82±3.24 vs 23.69±3.86,t=10.087,P<0.001;18.05±2.81 vs 25.73±3.42,t=15.026,P<0.001).The serum KL-6 level in the moderate patients was higher than that in the mild patients (P<0.05); the serum KL-6 level in the study group was negatively correlated with the levels of CD4⁺ and CD8⁺ (r=-0.526,P<0.001,r=-0.713,P<0.001),and with the DSA 28 score,the degree of pulmonary ventilation disorder,and the degree of pulmonary diffusion dysfunction were positively correlated (r=0.429,P<0.001,r=0.802,P<0.001,r=0.851,P<0.001); the serum KL-6 levels in patients with poor efficacy before treatment 1 month,3 months and 6 months of treatment were higher than those in patients with good efficacy (P<0.05); the area under the curve (AUC) of serum KL-6 level before treatment for predicting poor efficacy in patients with RA and ILD was 0.838,and the predictive sensitivity and specificity were 75.02% and 88.14%,respectively. Conclusion: The level of serum KL-6 in RA patients with ILD is significantly increased,and its level is closely related to the abnormality of T lymphocyte subsets,and it can assist in clinical evaluation of patients' condition and predict curative effect,and has high application value.

Key words： Rheumatoid arthritis Interstitial lung disease Salivary glycan antigen-6 T lymphocyte subsets

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	CHEN Lihua
	LAN Zhonghai
	FANG Tianxing
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Cite this article:

CHEN Lihua,LAN Zhonghai,FANG Tianxing, et al. Serum KL-6 Level and Its Relationship with T Lymphocyte Subsets in RA Patients with Interstitial Lung Disease[J]. HeBei Med, 2022, 28(7): 1112-1117.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2022.07.013 OR http://www.hbyxzzs.cn/EN/Y2022/V28/I7/1112

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