高迁移率族蛋白B1 PCT TGF-β1在新生儿肺炎中的表达水平及意义

doi:10.3969/j.issn.1006-6233.2022.07.011

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Abstract Objective: To analyze the expression levels and significance of HMGB1,PCT and TGF-β1 in neonates with pneumonia. Methods: Eighty children with neonatal pneumonia admitted to our hospital from January 2020 to January 2021 were selected as the neonatal pneumonia group.According to the bacterial infection or not,they were divided into non-bacterial infection group and bacterial infection group,and according to the severity of the disease,they were divided into mild group (34 cases),moderate syndrome group (25 cases) and severe group (21 cases).According to the disease recovery,the patients were divided into acute stage group (50 cases) and remission stage group (30 cases).In addition,80 healthy neonates in the Department of Neonatology of our hospital were selected as healthy control group.The venous blood of all subjects was extracted,and the expression levels of HMGB1 and TGF-β1 were determined by double-antibody sandwich ELISA method,and the expression levels of PCT were detected by flying immunofluorescence detector,and their correlation was analyzed. Results: The expression levels of SERUM HMGB1,PCT and TGF-β1 in neonatal pneumonia group were higher than those in healthy control group (P<0.05).The expression levels of SERUM HMGB1,PCT and TGF-β1 in the bacterial infection group were higher than those in the non-bacterial infection group (P<0.05).The levels of serum HMGB1,PCT and TGF-β1 in severe group were higher than those in mild and moderate group (P<0.05).The expression levels of SERUM HMGB1,PCT and TGF-β1 in acute group were higher than those in recovery group (P<0.05).HMGB1 was positively correlated with PCT (r=0.261,P=0.019).HMGB1 was positively correlated with TGF-β1 (r=0.245,P=0.027).PCT was positively correlated with TGF-β1 (r=0.479,P=0.001). Conclusion: The high expression of HMGB1,PCT and TGF-β1 in neonatal pneumonia was positively correlated with bacterial infection,severity and disease outcome,and all three were involved in the occurrence and development of this disease.

Key words： High mobility family protein B1 Procalcitonin Vascular transforming growth factor β1 Neonatal pneumonia

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2022.07.011 OR http://www.hbyxzzs.cn/EN/Y2022/V28/I7/1103

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