阿替普酶联合小剂量替罗非班对急性脑梗死患者血清细胞因子NIHSS评分的影响

doi:10.3969/j.issn.1006-6233.2022.06.036

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Abstract Objective: To explore the effect of alteplase (rt-PA) combined with low-dose tirofiban on serum cytokines and the National Institutes of Health Stroke Scale (NIHSS) score of patients with acute ischemic stroke (AIS). Methods: According to the order of admission, 145 patients with AIS were divided into combination group (n=49), positive control group (n=48), and negative control group (n=48). Patients in the negative control group were given conventional treatment, patients in the positive control group were treated with rt-PA on the basis of conventional treatment, and patients in the combination group were treated with rt-PA combined with low-dose tirofiban on the basis of conventional treatment. The carotid intima-media thickness ( C-IMT), carotid plaque score (Crouse score), serum levels of high-sensitivity C-reactive protein (hs-CRP), interleukin 17 (IL-17) and vascular endothelial growth factor (VEGF), and safety indexes were compared among the 3 groups. The NIHSS and Activity of Daily Living Scale (ADL) were used to evaluate nerve function and self-care ability on the day of admission and after the end of treatment. The prognosis was judged based on the modified Rankin Scale (mRS) score at 3 months after the end of the treatment, namely, the score≤1 indicated good prognosis, and the score≥2 indicated poor prognosis. The good prognosis rate was compared among the groups. Results: After treatment, C-IMT, Crouse score, serum levels of hs-CRP, IL-17 and VEGF, and NIHSS score were significantly decreased, while ADL score was significantly increased in the 3 groups (P<0.05). The difference values of above indexes on the day of admission and after treatment in combination group were greater than those in positive control group and negative control group(P<0.05). There was no significant difference in adverse reactions among the three groups (P>0.05). The mRS score of combination group was significantly lower than that of positive control group or negative control group at 3 months after treatment, and the good prognosis rate was significantly higher than that in positive control group and negative control group(P<0.05). Conclusion: The treatment of rt-PA combined with low-dose tirofiban for AIS can effectively reduce C-IMT, Crouse score, serum levels of hs-CRP, IL-1 and VEGF, and NIHSS score, and increase ADL score, thus improving the prognosis.

Key words： Acute ischemic stroke Alteplase Tirofiban Serum cytokine Nerve function National Institutes of Health Stroke Scale

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	FU Jindao
	YANG Hui
	WANG Yingxia
	et al

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FU Jindao,YANG Hui,WANG Yingxia, et al. Effect of Alteplase Combined with Low-Dose Tirofiban on Serum Cytokines and NIHSS Score of Patients with Acute Ischemic Stroke[J]. HeBei Med, 2022, 28(6): 1041-1046.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2022.06.036 OR http://www.hbyxzzs.cn/EN/Y2022/V28/I6/1041

[1] Jin L,Zhou J,Shi W,et al.Effects of six types of aspirin combination medications for treatment of acute cerebral infarction in China:a network meta-analysis[J].Clin Pharm Ther,2019,44(1):91-101.
[2] Wu T,Li P,Sun D.Assessing the clinical efficacy of recombinant tissue plasminogen activator on acute cerebral infarction[J].Nanosci Nanotechnol,2020,20(12):7781-7786.
[3] 寇新慧,吴瑞鹏,陈淼,等.阿替普酶在ACI治疗中对血清氧化应激血管内皮功能和脑神经功能的影响[J].河北医学,2021,27(3):503-507.
[4] 中华医学会神经病学分会,中华医学会神经病学分会脑血管病学组.中国急性缺血性脑卒中诊治指南2018[J].中华神经科杂志,2018,51(9):666-682.
[5] Saito T,Itabashi R,Yazawa Y,et al.Clinical outcome of patients with large vessel occlusion and low national institutes of health stroke scale scores:subanalysis of the RESCUE-Japan registry 2[J].Stroke,2020,51(5):1458-1463.
[6] Pincus T,Summey JA,Soraci SA Jr,et al.Assessment of patient satisfaction in activities of daily living using a modified stanford health assessment questionnaire[J].Arthritis Rheum,1983,26(11):1346-1353.
[7] Yi K,Okazaki S,Inoue M,et al.Reliability of modified rankin scale assessment with a Japanese version of simplified modified rankin scale questionnaire (J-RASQ)[J].Rinsho Shinkeigaku,2019,59(7):399-404.
[8] Liu X,Rao S,Wang J.Intravenous thrombolysis in combination with mild hypothermia therapy in the treatment of acute cerebral infarction[J].Pak Med Sci,2019,35(4):1161-1166.
[9] 刘琳,罗华,刘洪,等.脑小血管病总体负担对脑梗死静脉溶栓疗效的影响[J].中国脑血管病杂志,2019,16(8):393-399.
[10] Rabinstein AA.Update on treatment of acute ischemic stroke[J].Continuum (Minneap Minn),2020,26(2):268-286.
[11] Lindgren E,Silvis SM,Hiltunen S,et al.Acute symptomatic seizures in cerebral venous thrombosis[J].Neurology,2020,95(12):1706-1715.
[12] 程建华,黄一睿,肖美娟,等.急性缺血性脑卒中大鼠脑组织中Th17/Treg的变化[J].中国病理生理杂志,2019,35(4):190-195,200.
[13] 郭连峰,牟娜,刘兆玮,等.老年急性脑梗死患者血清CRP、VEGF及YKL-40水平动态变化及相关性[J].中国老年学杂志,2020,40(1):14-19.
[14] 安小峰,崔惠康.阿替普酶联合替罗非班对急性脑梗死患者纤溶系统、神经功能及预后的影响[J].医学综述,2021,27(5):1027-1031,1036.