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Efficacy of Gamma Globulin Combined with Ribavirin in the Treatment of Children with Infectious Mononucleosis and Its Influence on TLR2, TLR9 and T Lymphocyte Subsets |
LI Mingyue, WANG Yan, YUE Jingwei |
Xi'an Children's Hospital, Shanxi Xi'an 710003, China |
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Abstract Objective: To investigate the efficacy of gamma globulin combined with ribavirin in the treatment of children with infectious mononucleosis (IM), and the influence on Toll-like receptor 2 (TLR2), Toll-like receptor 9 (TLR9) and T lymphocyte subsets. Methods: 226 children with IM admitted to the hospital were selected between March 2019 and March 2021. They were randomly divided into control group (111 cases) and study group (115 cases) by the random number table method. Children in the control group were treated with ribavirin, and children in the study group were treated with gamma globulin combined with ribavirin. Efficacy and clinical signs of the two groups were observed. The mRNA expression of TLR2 and TLR9, and the levels of T lymphocyte subsets (CD3+, CD4+, CD8+) in the two groups were compared before and after treatment. Results: The total effective rate of treatment in the study group was 92.17%, higher than 81.08% in the control group (P<0.05). The time for lymph node shrinking, time for liver and spleen shrinking, angina relief time, and fever abatement time in the study group were shorter than those in the control group (P<0.05). The difference of TLR2 and TLR9 mRNA levels in the study group before and after treatment was higher than that in the control group (P<0.05). The difference of CD3+, CD4+ and CD8+in the study group before and after treatment were higher than those in the control group (P<0.05). Conclusion: Gamma globulin combined with ribavirin is effective in the treatment of children with IM, which can significantly reduce the expression of TLR2 and TLR9 and improve immunity.
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